Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity - Test2 - elhamkhani - TriplyDB

Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity

Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity

http://www.wikidata.org/entity/Q24537309

about

Polo-like kinase 3 is required for entry into S phase Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing Role of Plk2 (Snk) in mouse development and cell proliferation Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration Regulation of PTEN stability and activity by Plk3 Polo-like kinases and the orchestration of cell division Caspase-2-mediated cell death is required for deleting aneuploid cells.Transcriptome analysis reveals potential mechanisms underlying differential heart development in fast- and slow-growing broilers under heat stress.Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.Polo-box domain: a versatile mediator of polo-like kinase function.Hormonal induction of polo-like kinases (Plks) and impact of Plk2 on cell cycle progression in the rat ovary.Effect of hypoxic stress-activated Polo-like kinase 3 on corneal epithelial wound healing Polo-like kinases and centrosome regulation.Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun.Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytes The mammalian centrosome and its functional significance Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma.Activation of Polo-like kinase 3 by hypoxic stresses.Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.Cytoskeletal architecture and cell motility remain unperturbed in mouse embryonic fibroblasts from Plk3 knockout mice.Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.ER-Golgi network--a future target for anti-cancer therapy.Effects of low doses of ionizing radiation exposures on stress-responsive gene expression in human embryonic stem cells.Targeting of polo-like kinases and their cross talk with Aurora kinases--possible therapeutic strategies in human acute myeloid leukemia?Current assessment of polo-like kinases as anti-tumor drug targets.Polo-like kinases: structural variations lead to multiple functions.The role of Plk3 in oncogenesis.Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects.Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response.Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization.

P2860

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P2860

Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity

http://www.wikidata.org/entity/Q24537309

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@ast

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@en

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@nl

type

label

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@ast

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@en

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@nl

prefLabel

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@ast

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@en

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@nl

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MCB.22.10.3450-3459.2002

P1433

Molecular and Cellular Biology

P1476

Cell cycle arrest and apoptosi ...... ation of microtubule integrity

@en

P2093

Jie Chen

http://www.w3.org/2001/XMLSchema#string

Kenji Fukasawa

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Meena Jhanwar-Uniyal

http://www.w3.org/2001/XMLSchema#string

Qi Wang

http://www.w3.org/2001/XMLSchema#string

Suqing Xie

http://www.w3.org/2001/XMLSchema#string

Ulhas Naik

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Wei Dai

http://www.w3.org/2001/XMLSchema#string

P2860

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5

Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures.

Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas

The physical association and phosphorylation of Cdc25C protein phosphatase by Prk

PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions

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3450-9

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scholarly article

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1314103

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10.1128/MCB.22.10.3450-3459.2002

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P407

P433

10

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22

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P50

Zbyszek Darzynkiewicz

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2002-05-01T00:00:00Z

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P5875

11396397

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P698

11971976

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P921

apoptotic process

P932

133784

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