Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerCentrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyThe p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancersThe centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesionThe novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolusDishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1.Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarityNek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesisPlk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBoraA centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrestProteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cellsPolo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyThe centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM componentsAssociation of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complexThe mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplicationCell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrityPlk phosphorylation regulates the microtubule-stabilizing protein TCTP.The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centriolesThe transition from meiotic to mitotic spindle assembly is gradual during early mammalian developmentThe crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complexAurora-A kinase is required for centrosome maturation in Caenorhabditis elegansThe checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesisRequirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomesPeripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindlesRole of Plk2 (Snk) in mouse development and cell proliferationMultisite phosphorylation of Pin1-associated mitotic phosphoproteins revealed by monoclonal antibodies MPM-2 and CC-3Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentMolecular dynamics of PLK1 during mitosisInfluenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome MaturationMultiple requirements of PLK1 during mouse oocyte maturation
P2860
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P2860
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Antibody microinjection reveal ...... uration of mitotic centrosomes
@ast
Antibody microinjection reveal ...... uration of mitotic centrosomes
@en
Antibody microinjection reveal ...... uration of mitotic centrosomes
@en-gb
Antibody microinjection reveal ...... uration of mitotic centrosomes
@nl
type
label
Antibody microinjection reveal ...... uration of mitotic centrosomes
@ast
Antibody microinjection reveal ...... uration of mitotic centrosomes
@en
Antibody microinjection reveal ...... uration of mitotic centrosomes
@en-gb
Antibody microinjection reveal ...... uration of mitotic centrosomes
@nl
prefLabel
Antibody microinjection reveal ...... uration of mitotic centrosomes
@ast
Antibody microinjection reveal ...... uration of mitotic centrosomes
@en
Antibody microinjection reveal ...... uration of mitotic centrosomes
@en-gb
Antibody microinjection reveal ...... uration of mitotic centrosomes
@nl
P2860
P921
P3181
P356
P1476
Antibody microinjection reveal ...... uration of mitotic centrosomes
@en
P2093
P2860
P304
P3181
P356
10.1083/JCB.135.6.1701
P407
P433
P577
1996-12-01T00:00:00Z