Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
about
Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypesIdentification of direct protein targets of small moleculesCytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factorsA short Nur77-derived peptide converts Bcl-2 from a protector to a killerInhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteinsGain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functionsThe Bcl-2 apoptotic switch in cancer development and therapyTargeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signalingDirect inhibition of the NOTCH transcription factor complexAll-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.BH3 mimetics to improve cancer therapy; mechanisms and examplesMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsMulti-Facial, Non-Peptidic α-Helix MimeticsTargeting BCL2-Proteins for the Treatment of Solid TumoursThe click reaction as an efficient tool for the construction of macrocyclic structuresFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreElucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domainsGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsTargeting the apoptosis pathway in hematologic malignanciesInhibition of nutlin-resistant HDM2 mutants by stapled peptidesStapled BH3 peptides against MCL-1: mechanism and design using atomistic simulationsBAX activation is initiated at a novel interaction siteHigh-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xLDeterminants of BH3 Binding Specificity for Mcl-1 versus Bcl-xLA Left-Handed Solution to Peptide Inhibition of the p53-MDM2 InteractionThe MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizerD-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasmsStructural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based DesignRational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 InhibitorsDevelopment of a Peptide that Selectively Activates Protein Phosphatase-1 in Living CellsInhibition of oncogenic Wnt signaling through direct targeting of -cateninComputational Design of Thermostabilizing d -Amino Acid SubstitutionsEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainBID-induced structural changes in BAK promote apoptosisStructure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival ProteinsStapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapyDiscovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein AOxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic speciesRational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces
P2860
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P2860
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
@nl
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@ast
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@en
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@en-gb
type
label
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
@nl
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@ast
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@en
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@en-gb
prefLabel
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
@nl
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@ast
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@en
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@en-gb
P2093
P2860
P3181
P356
P1433
P1476
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
@en
P2093
Andrew L Kung
Gerhard Wagner
Gregory L Verdine
Iris Escher
Loren D Walensky
Renee D Wright
Scott Barbuto
Stanley J Korsmeyer
Thomas J Malia
P2860
P304
P3181
P356
10.1126/SCIENCE.1099191
P407
P577
2004-09-01T00:00:00Z