Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors - Test2 - elhamkhani - TriplyDB

Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors

Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors

http://www.wikidata.org/entity/Q24548490

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Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513 GABA A receptors: subtypes provide diversity of function and pharmacology International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update The genetics of substance dependence Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons Pseudocontinuous arterial spin labeling reveals dissociable effects of morphine and alcohol on regional cerebral blood flow Ethanol effects on GABA-gated current in a model of increased alpha4betadelta GABAA receptor expression depend on time course and preexposure to low concentrations of the drug.The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress Low dose acute alcohol effects on GABA A receptor subtypes GABAA receptor subtypes: the "one glass of wine" receptors.Molecular targets and mechanisms for ethanol action in glycine receptors Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.Alcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors.Stress, ethanol, and neuroactive steroids Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.GABAA receptor subtype involvement in addictive behaviour.Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.Alcohol-sensitive GABA receptors and alcohol antagonists.GABAA receptors in the posterior, but not anterior, ventral tegmental area mediate Ro15-4513-induced attenuation of binge-like ethanol consumption in C57BL/6J female mice The role of GABA(A) receptors in the development of alcoholism A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513.The effects of hypoglycemic and alcoholic coma on the blood-brain barrier permeability Oxytocin prevents ethanol actions at δ subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs Low concentrations of ethanol do not affect radioligand binding to the delta-subunit-containing GABAA receptors in the rat brain.Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results Tonic for what ails us? high-affinity GABAA receptors and alcohol Mechanisms of neurosteroid interactions with GABA(A) receptors.Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro.Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors.Ethanol Regulation of Synaptic GABAA α4 Receptors Is Prevented by Protein Kinase A Activation.Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol.Low Doses of Ethanol Enhance LTD-like Plasticity in Human Motor Cortex.Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice.GABA(A) receptors and alcohol.

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P2860

Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors

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2006 nî lūn-bûn

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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2006 թվականի մայիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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Proceedings of the National Academy of Sciences of the United States of America

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Ethanol potently and competiti ...... a4/6beta3delta GABAA receptors

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H Jacob Hanchar

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Martin Wallner

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Panida Chutsrinopkun

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Porntip Supavilai

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Pratap Meera

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Richard W Olsen

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Werner Sieghart

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P2860

Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513

Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus

Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

Cerebellar GABAA receptor selective for a behavioural alcohol antagonist

Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat

Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors

Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.

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103

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