The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis
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Alpha thalassaemia-mental retardation, X linkedThe SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genomeInteraction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardationATRX dysfunction induces replication defects in primary mouse cellsATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndromeATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cellsMembers of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neuronsCalcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activationSnf2l regulates Foxg1-dependent progenitor cell expansion in the developing brainLoss of ATRX does not confer susceptibility to osteoarthritisComparative analysis of the ATRX promoter and 5' regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular functionRole of BRCA1 in brain development.Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neuronsLoss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cellsLoss of ATRX in chondrocytes has minimal effects on skeletal developmentAbnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardationDecreased expression of GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome.Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivoAnalysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin loopingConditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brainLack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathwaysFruit flies and intellectual disability.An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke.ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain.Role of ATRX in chromatin structure and function: implications for chromosome instability and human diseaseDefining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse modelATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.Compromised genomic integrity impedes muscle growth after Atrx inactivation.X-linked mental retardation and epigenetics.Epigenetic mechanisms in neurological diseaseAtrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikisPHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas.Mosaic expression of Atrx in the mouse central nervous system causes memory deficits.
P2860
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P2860
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis
description
2005 nî lūn-bûn
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2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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name
The chromatin-remodeling prote ...... survival during corticogenesis
@ast
The chromatin-remodeling prote ...... survival during corticogenesis
@en
The chromatin-remodeling prote ...... survival during corticogenesis
@nl
type
label
The chromatin-remodeling prote ...... survival during corticogenesis
@ast
The chromatin-remodeling prote ...... survival during corticogenesis
@en
The chromatin-remodeling prote ...... survival during corticogenesis
@nl
prefLabel
The chromatin-remodeling prote ...... survival during corticogenesis
@ast
The chromatin-remodeling prote ...... survival during corticogenesis
@en
The chromatin-remodeling prote ...... survival during corticogenesis
@nl
P2093
P2860
P3181
P356
P1476
The chromatin-remodeling prote ...... survival during corticogenesis
@en
P2093
David Garrick
David J Picketts
Douglas R Higgs
Jackie Vanderluit
Magdalena Jagla
Marie Mangelsdorf
Nathalie G Bérubé
Richard J Gibbons
Ruth S Slack
P2860
P304
P3181
P356
10.1172/JCI22329
P407
P577
2005-02-01T00:00:00Z