Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47 - Test2 - elhamkhani - TriplyDB

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47

http://www.wikidata.org/entity/Q24561405

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Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2 Perspectives on anti-CD47 antibody treatment for experimental cancer Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47 Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy Radiotherapy combination opportunities leveraging immunity for the next oncology practice A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition Harnessing the antitumor potential of macrophages for cancer immunotherapy The impact of the myeloid response to radiation therapy Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression Mini-chaperones: potential immuno-stimulators in vaccine design Targeting the innate immune system as immunotherapy for acute myeloid leukemia Review of Cisplatin and oxaliplatin in current immunogenic and monoclonal antibody treatments Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines Calreticulin (CALR) mutation in myeloproliferative neoplasms (MPNs)CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells.Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.Tumor Cells Surviving Exposure to Proton or Photon Radiation Share a Common Immunogenic Modulation Signature, Rendering Them More Sensitive to T Cell-Mediated Killing Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain.Diversity and Versatility of Phagocytosis: Roles in Innate Immunity, Tissue Remodeling, and Homeostasis.Calreticulin is a novel independent prognostic factor for oral squamous cell carcinoma Synthetic induction of immunogenic cell death by genetic stimulation of endoplasmic reticulum stress.CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice.Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients.Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity.Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk.Combating HER2-overexpressing breast cancer through induction of calreticulin exposure by Tras-Permut CrossMab.

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P2860

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47

http://www.wikidata.org/entity/Q24561405

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

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name

Calreticulin is the dominant p ...... and is counterbalanced by CD47

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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type

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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prefLabel

Calreticulin is the dominant p ...... and is counterbalanced by CD47

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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SCITRANSLMED.3001375

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Science Translational Medicine

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Calreticulin is the dominant p ...... and is counterbalanced by CD47

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P2093

Andrew J Gentles

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Ash A Alizadeh

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Christopher Y Park

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Irving L Weissman

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Jens Volkmer

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Kipp Weiskopf

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Mark P Chao

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Rachel Weissman-Tsukamoto

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Ravindra Majeti

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Siddhartha Jaiswal

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P2860

The Hallmarks of Cancer

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly

Stem cells, cancer, and cancer stem cells

Identification of human brain tumour initiating cells

Identification of a cancer stem cell in human brain tumors

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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63ra94

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2233908

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10.1126/SCITRANSLMED.3001375

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63

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2

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2010-12-22T00:00:00Z

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21178137

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4126904

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