Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
about
Maturation of human cyclin E requires the function of eukaryotic chaperonin CCTCyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancersCullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsPolo-like kinase 3 is required for entry into S phaseThe stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γAssociation of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathwayModulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirusMutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapyThe ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transitionMicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradationA comprehensive pathway map of epidermal growth factor receptor signalingCyclins in breast cancer: too much of a good thing.Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeastGlycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationThe structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent rolesConstitutive turnover of cyclin E by Cul3 maintains quiescenceTargeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplicationSCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progressionEffects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplicationMurine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.Molecular interaction map of the mammalian cell cycle control and DNA repair systems.Proteasome-mediated degradation of the papillomavirus E2-TA protein is regulated by phosphorylation and can modulate viral genome copy number.Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer.Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasomeInsulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibitionTumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight formsAdenovirus E1A-regulated transcription factor p120E4F inhibits cell growth and induces the stabilization of the cdk inhibitor p21WAF1.Tomato SlSnRK1 protein interacts with and phosphorylates βC1, a pathogenesis protein encoded by a geminivirus β-satellite.Murine coronavirus replication induces cell cycle arrest in G0/G1 phase.Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells.ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cellsTransferable domain in the G(1) cyclin Cln2 sufficient to switch degradation of Sic1 from the E3 ubiquitin ligase SCF(Cdc4) to SCF(Grr1).Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Cell kinetics and cell cycle regulation in lymphomas.
P2860
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P2860
Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@ast
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@en
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@nl
type
label
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@ast
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@en
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@nl
prefLabel
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@ast
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@en
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@nl
P2860
P1433
P1476
Activation of cyclin E/CDK2 is ...... endent degradation of cyclin E
@en
P2093
P2860
P304
P407
P577
1996-08-15T00:00:00Z