Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase
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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cellsIdentification of unique mechanisms for triterpene biosynthesis in Botryococcus brauniiThe maximal affinity of ligandsHuman isoprenoid synthase enzymes as therapeutic targetsKes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution.Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretionFarnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactionsComparison of Chemical Sensitivity of Fresh and Long-Stored Heat Resistant Neosartorya fischeri Environmental Isolates Using BIOLOG Phenotype MicroArray SystemA squalene synthase-like enzyme initiates production of tetraterpenoid hydrocarbons in Botryococcus braunii Race LThe effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cellsHepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acidsThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng.Functional microdomains in bacterial membranesSilyl glyoxylates. Conception and realization of flexible conjunctive reagents for multicomponent coupling.Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae.Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus.Exploring the existence of lipid rafts in bacteria.New lipid-lowering agents.Squalestatin is an inhibitor of carotenoid biosynthesis in Plasmodium falciparum.Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesisLipid-lowering therapies in development.Highly stereoselective C-C bond formation by rhodium-catalyzed tandem ylide formation/[2,3]-sigmatropic rearrangement between donor/acceptor carbenoids and chiral allylic alcohols.Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast.Quinuclidine derivatives as potential antiparasiticsRecent developments in the treatment of atherosclerosis.Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiaeA yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex.Cloning, solubilization, and characterization of squalene synthase from Thermosynechococcus elongatus BP-1Self-consistent synthesis of the squalene synthase inhibitor zaragozic acid C via controlled oligomerizationEnantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor developmentGeranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.Metabolism, LXR/LXR ligands, and tumor immune escape.Multi-species biofilms: how to avoid unfriendly neighbors.Regulation of dolichol-linked glycosylation.
P2860
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P2860
Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@ast
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@en
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@nl
type
label
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@ast
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@en
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@nl
prefLabel
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@ast
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@en
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@nl
P2093
P2860
P3181
P356
P1476
Zaragozic acids: a family of f ...... nhibitors of squalene synthase
@en
P2093
C Dufresne
F L VanMiddlesworth
J D Bergstrom
J D Karkas
O D Hensens
R G Bostedor
V S Bansal
P2860
P3181
P356
10.1073/PNAS.90.1.80
P407
P577
1993-01-01T00:00:00Z