Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase - Test2 - elhamkhani - TriplyDB

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

http://www.wikidata.org/entity/Q24563858

about

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii The maximal affinity of ligands Human isoprenoid synthase enzymes as therapeutic targets Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution.Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions Comparison of Chemical Sensitivity of Fresh and Long-Stored Heat Resistant Neosartorya fischeri Environmental Isolates Using BIOLOG Phenotype MicroArray System A squalene synthase-like enzyme initiates production of tetraterpenoid hydrocarbons in Botryococcus braunii Race L The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng.Functional microdomains in bacterial membranes Silyl glyoxylates. Conception and realization of flexible conjunctive reagents for multicomponent coupling.Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae.Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus.Exploring the existence of lipid rafts in bacteria.New lipid-lowering agents.Squalestatin is an inhibitor of carotenoid biosynthesis in Plasmodium falciparum.Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis Lipid-lowering therapies in development.Highly stereoselective C-C bond formation by rhodium-catalyzed tandem ylide formation/[2,3]-sigmatropic rearrangement between donor/acceptor carbenoids and chiral allylic alcohols.Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast.Quinuclidine derivatives as potential antiparasitics Recent developments in the treatment of atherosclerosis.Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex.Cloning, solubilization, and characterization of squalene synthase from Thermosynechococcus elongatus BP-1 Self-consistent synthesis of the squalene synthase inhibitor zaragozic acid C via controlled oligomerization Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.Metabolism, LXR/LXR ligands, and tumor immune escape.Multi-species biofilms: how to avoid unfriendly neighbors.Regulation of dolichol-linked glycosylation.

P2860

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P2860

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

http://www.wikidata.org/entity/Q24563858

description

1993 nî lūn-bûn

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1993 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1993 թվականի հունվարին հրատարակված գիտական հոդված

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1993年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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Zaragozic acids: a family of f ...... nhibitors of squalene synthase

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P2093

A M Amend

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C Dufresne

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D J Rew

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F L VanMiddlesworth

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J D Bergstrom

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J D Karkas

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M M Kurtz

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O D Hensens

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R G Bostedor

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V S Bansal

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P2860

Molecular cloning and characterization of the yeast gene for squalene synthetase

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

Inhibition of squalene synthetase by farnesyl pyrophosphate analogues

Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699

NB-598: a potent competitive inhibitor of squalene epoxidase.

Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation.

The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.

A new intermediate in the biosynthesis of squalene.

The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation.

Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.

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80-4

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2458953

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10.1073/PNAS.90.1.80

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1

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90

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8419946

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45603

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