Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent - Test2 - elhamkhani - TriplyDB

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

http://www.wikidata.org/entity/Q24613185

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The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention Lovastatin production by Aspergillus terreus using agro-biomass as substrate in solid state fermentation Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase Pleiotropic effects of statins Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation Pleiotropic effects of statins in the diseases of the liver Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders Exploiting the Biosynthetic Potential of Type III Polyketide Synthases Statins: definitive translational research Cholesterol is required for infection by Semliki Forest virus Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing.Overlapping functions of the yeast oxysterol-binding protein homologues.Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.A century of cholesterol and coronaries: from plaques to genes to statins Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10 Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part V: the discovery of the statins and the end of the controversy Lovastatin decreases coenzyme Q levels in humans The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699 Antiviral activity of lovastatin against respiratory syncytial virus in vivo and in vitro The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor Plasma mevalonate as a measure of cholesterol synthesis in man Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system High-content, image-based screening for drug targets in yeast Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway.Chemical ecology: a view from the pharmaceutical industry Effect of butyrolactone I on the producing fungus, Aspergillus terreus.The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Classification of a large microarray data set: algorithm comparison and analysis of drug signatures.Importance of microbial natural products and the need to revitalize their discovery.Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway.Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin.

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P2860

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

http://www.wikidata.org/entity/Q24613185

description

1980 nî lūn-bûn

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1980 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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1980 թվականի հուլիսին հրատարակված գիտական հոդված

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1980年の論文

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1980年学术文章

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1980年学术文章

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1980年学术文章

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1980年学术文章

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Mevinolin: a highly potent com ...... d a cholesterol-lowering agent

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Mevinolin: a highly potent com ...... d a cholesterol-lowering agent

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Mevinolin: a highly potent com ...... d a cholesterol-lowering agent

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Mevinolin: a highly potent com ...... d a cholesterol-lowering agent

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Mevinolin: a highly potent com ...... d a cholesterol-lowering agent

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Proceedings of the National Academy of Sciences of the United States of America

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Mevinolin: a highly potent com ...... d a cholesterol-lowering agent

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A Patchett

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A W Alberts

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C Hoffman

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E Harris

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E Stapley

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G Albers-Schonberg

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G Kuron

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J Chen

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J Hirshfield

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P2860

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

The determination of enzyme inhibitor constants

Cholesterol metabolism in man

Hypolipidemic effects in monkeys of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.

Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Therapeutic effects of ML-236B in primary hypercholesterolemia.

Purification of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver.

Kinetic analysis of the reaction catalyzed by rat-liver 3-hydroxy-3-methylglutaryl-coenzyme-A reductase using two specific inhibitors.

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3957-61

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10.1073/PNAS.77.7.3957

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7

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