11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics - Test2 - elhamkhani - TriplyDB

11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

http://www.wikidata.org/entity/Q24564713

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Local amplification of glucocorticoids in the aging brain and impaired spatial memory Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome Brain mineralocorticoid receptors in cognition and cardiovascular homeostasis Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury Tales of a Dirty Drug: Carbenoxolone, Gap Junctions, and Seizures Compound library development guided by protein structure similarity clustering and natural product structure Charting biologically relevant chemical space: a structural classification of natural products (SCONP)Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls.Is 11beta-hydroxysteroid dehydrogenase type 1 a good therapeutic target for blockade of glucocorticoid actions?Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study.Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats.A prospective study of diurnal cortisol and cognitive function in community-dwelling elderly people.Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke Evidence for expression of 11β-hydroxysteroid dehydrogenase type3 (HSD11B3/HSD11B1L) in neonatal pig testis.Bidirectional metabolic regulation of neurocognitive function.High postoperative serum cortisol level is associated with increased risk of cognitive dysfunction early after coronary artery bypass graft surgery: a prospective cohort study.11β-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men.11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways.Aging and stress: past hypotheses, present approaches and perspectives Identification of important chemical features of 11β-hydroxysteroid dehydrogenase type1 inhibitors: application of ligand based virtual screening and density functional theory Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids.Inhibition of 11beta-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease.Why is the management of glucocorticoid deficiency still controversial: a review of the literature.Do corticosteroids damage the brain?Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease.11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses The relationship between type 2 diabetes and dementia.Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice.11beta-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents.Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline.

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11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

http://www.wikidata.org/entity/Q24564713

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2004年の論文

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11Beta-hydroxysteroid dehydrog ...... derly men and type 2 diabetics

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11Beta-hydroxysteroid dehydrog ...... derly men and type 2 diabetics

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Proceedings of the National Academy of Sciences of the United States of America

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11Beta-hydroxysteroid dehydrog ...... derly men and type 2 diabetics

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Alasdair M J MacLullich

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Brian R Walker

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Ian J Deary

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Jonathan R Seckl

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Joyce L W Yau

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June Noble

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Thekkepat C Sandeep

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Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2

The hospital anxiety and depression scale

Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme

Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action

Does central obesity reflect "Cushing's disease of the omentum"?

Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase

Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization

11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?

11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess

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