Compound library development guided by protein structure similarity clustering and natural product structure - Test2 - elhamkhani - TriplyDB

Compound library development guided by protein structure similarity clustering and natural product structure

Compound library development guided by protein structure similarity clustering and natural product structure

http://www.wikidata.org/entity/Q30344285

about

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases Charting biologically relevant chemical space: a structural classification of natural products (SCONP)Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.Finding Inspiration in the Protein Data Bank to Chemically Antagonize Readers of the Histone Code.1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain.Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries.Principles, implementation, and application of biology-oriented synthesis (BIOS).Small molecule macroarray construction via palladium-mediated carbon-carbon bond-forming reactions: highly efficient synthesis and screening of stilbene arrays.Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products.Recent trends and observations in the design of high-quality screening collections.Towards the systematic exploration of chemical space.Biology-oriented synthesis.Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway.Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs.Chemogenomics in drug discovery: computational methods based on the comparison of binding sites.Predicting natural product value, an exploration of anti-TB drug space.Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.Mouse 11β-hydroxysteroid dehydrogenase type 2 for human application: homology modeling, structural analysis and ligand-receptor interaction.Synthesis of the B-seco limonoid core scaffold.Synthesis of natural-product-like molecules with over eighty distinct scaffolds Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis.BIOS: Similarity-based design of natural product derived compound collections.Putting small molecules in the lead.Synthesis of the B-seco limonoid scaffold A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones Stereocomplementary synthesis of a natural product-derived compound collection on a solid phase

P2860

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P2860

Compound library development guided by protein structure similarity clustering and natural product structure

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2004 nî lūn-bûn

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2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2004 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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Compound library development g ...... and natural product structure

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Compound library development g ...... and natural product structure

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Compound library development g ...... and natural product structure

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Compound library development g ...... and natural product structure

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Proceedings of the National Academy of Sciences of the United States of America

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Compound library development g ...... and natural product structure

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Alex Odermatt

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Duraiswamy A Jeyaraj

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Eleni Gourzoulidou

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Kerstin Reinecke

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Lars-Oliver Wittenberg

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Marcus A Koch

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Sudipta Basu

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P2860

Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase

11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

A new and rapid colorimetric determination of acetylcholinesterase activity

Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A

SCOP: a structural classification of proteins database for the investigation of sequences and structures

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path

Target-oriented and diversity-oriented organic synthesis in drug discovery

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies

Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein

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10.1073/PNAS.0404719101

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48

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101

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Herbert Waldmann

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2004-11-17T00:00:00Z

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