Computational redesign of endonuclease DNA binding and cleavage specificity - Test2 - elhamkhani - TriplyDB

Computational redesign of endonuclease DNA binding and cleavage specificity

Computational redesign of endonuclease DNA binding and cleavage specificity

http://www.wikidata.org/entity/Q24569661

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Computational design of a red fluorophore ligase for site-specific protein labeling in living cells Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds Computational design of Candida boidinii xylose reductase for altered cofactor specificity Design of protein-ligand binding based on the molecular-mechanics energy model Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences Catalytic domain of restriction endonuclease BmrI as a cleavage module for engineering endonucleases with novel substrate specificities Homing endonuclease I-CreI derivatives with novel DNA target specificities Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and Dynamics Homing endonucleases: DNA scissors on a mission The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins Alteration of enzyme specificity by computational loop remodeling and design Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus Evolution of I-SceI Homing Endonucleases with Increased DNA Recognition Site Specificity Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface Visualizing phosphodiester-bond hydrolysis by an endonuclease Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite Biology by design: reduction and synthesis of cellular components and behaviour Combined covalent-electrostatic model of hydrogen bonding improves structure prediction with Rosetta RosettaBackrub--a web server for flexible backbone protein structure modeling and design Backrub-like backbone simulation recapitulates natural protein conformational variability and improves mutant side-chain prediction Genome Engineering With Zinc-Finger Nucleases Effects of Non-Natural Amino Acid Incorporation into the Enzyme Core Region on Enzyme Structure and Function.Optimizing scoring function of protein-nucleic acid interactions with both affinity and specificity.Assessment of protein side-chain conformation prediction methods in different residue environments.Computational approaches for rational design of proteins with novel functionalities OptGraft: A computational procedure for transferring a binding site onto an existing protein scaffold.A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.Sub-AQUA: real-value quality assessment of protein structure models.Specificity in computational protein design Achievements and Challenges in Computational Protein Design.Effective inter-residue contact definitions for accurate protein fold recognition LAHEDES: the LAGLIDADG homing endonuclease database and engineering server Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification.

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P2860

Computational redesign of endonuclease DNA binding and cleavage specificity

http://www.wikidata.org/entity/Q24569661

description

2006 nî lūn-bûn

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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2006 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Computational redesign of endonuclease DNA binding and cleavage specificity

@ast

Computational redesign of endonuclease DNA binding and cleavage specificity

@en

Computational redesign of endonuclease DNA binding and cleavage specificity

@nl

type

label

Computational redesign of endonuclease DNA binding and cleavage specificity

@ast

Computational redesign of endonuclease DNA binding and cleavage specificity

@en

Computational redesign of endonuclease DNA binding and cleavage specificity

@nl

prefLabel

Computational redesign of endonuclease DNA binding and cleavage specificity

@ast

Computational redesign of endonuclease DNA binding and cleavage specificity

@en

Computational redesign of endonuclease DNA binding and cleavage specificity

@nl

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Computational redesign of endonuclease DNA binding and cleavage specificity

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P2093

Barry L Stoddard

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Carlos M Duarte

http://www.w3.org/2001/XMLSchema#string

Django Sussman

http://www.w3.org/2001/XMLSchema#string

James J Havranek

http://www.w3.org/2001/XMLSchema#string

Raymond J Monnat

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations altering the cleavage specificity of a homing endonuclease

Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities

Protein-DNA binding specificity predictions with structural models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI

The structure of I-Crel, a group I intron-encoded homing endonuclease

Directed evolution and substrate specificity profile of homing endonuclease I-SceI.

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Isolation and characterization of new homing endonuclease specificities at individual target site positions

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

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656-9

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1832877

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10.1038/NATURE04818

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7093

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441

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Justin Ashworth

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2006-06-01T00:00:00Z

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7043592

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1012756616

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16738662

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computational biology

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2999987

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