Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities
about
Computational redesign of endonuclease DNA binding and cleavage specificityHoming endonuclease mediated gene targeting in Anopheles gambiae cells and embryosMolecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamidesFour base recognition by triplex-forming oligonucleotides at physiological pH.Developing a programmed restriction endonuclease for highly specific DNA cleavageEpCAM in carcinogenesis: the good, the bad or the uglyOptimizing scoring function of protein-nucleic acid interactions with both affinity and specificity.In vitro selection of restriction endonucleases by in vitro compartmentalizationSequence-specific positions of water molecules at the interface between DNA and minor groove binders.A novel FRET pair for detection of parallel DNA triplexes by the LightCyclerNetropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors.Selection of RNA aptamers that bind HIV-1 LTR DNA duplexes: strand invaders.Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer.Synthetic zinc finger peptides: old and novel applications.Cell-specific targeting of lipid-based carriers for ODN and DNA.Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes.Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer.Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dicationTriplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells.Targeted Gene Activation Using RNA-Guided Nucleases.Investigation of arc repressor DNA-binding specificity by comparative molecular dynamics simulations.Statistical analysis of structural determinants for protein-DNA-binding specificity.Influence of substituent modifications on the binding of 2-amino-1,8-naphthyridines to cytosine opposite an AP site in DNA duplexes: thermodynamic characterization.Zinc finger protein binding to DNA: an energy perspective using molecular dynamics simulation and free energy calculations on mutants of both zinc finger domains and their specific DNA bases.Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies.Base-pairing behavior of a carbocyclic Janus-AT nucleoside analogue capable of recognizing A and T within a DNA duplex.Sliding on DNA: From Peptides to Small Molecules.Re-expressing Epigenetically Silenced Genes by Inducing DNA Demethylation Through Targeting of Ten-Eleven Translocation 2 to Any Given Genomic Locus.The past and presence of gene targeting: from chemicals and DNA via proteins to RNA.Enhanced Inhibition of Transcription Start by Targeting with 2′-OMe Pentaribonucleotides Comprising Locked Nucleic Acids and Intercalating Nucleic Acids
P2860
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P2860
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@ast
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@en
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@nl
type
label
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@ast
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@en
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@nl
prefLabel
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@ast
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@en
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@nl
P2093
P2860
P356
P1476
Therapeutic modulation of endo ...... ned DNA-sequence specificities
@en
P2093
Hidde J Haisma
Marianne G Rots
Taco G Uil
P2860
P304
P356
10.1093/NAR/GKG815
P407
P577
2003-11-01T00:00:00Z