The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
about
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcBtRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humansDivergent allosteric control of the IRE1α endoribonuclease using kinase inhibitorsRole for the Unfolded Protein Response in Heart Disease and Cardiac ArrhythmiasThe Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for TreatmentThe unfolded protein response in neurodegenerative diseases: a neuropathological perspectiveEndoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the UglyDrugging the unfolded protein response in acute leukemiasProtein homeostasis as a therapeutic target for diseases of protein conformationStructure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitorsToll-like receptors in the pathogenesis of autoimmune diseases: recent and emerging translational developmentsNovel therapeutic strategies for multiple myelomaTumor progression and the different faces of the PERK kinaseHrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosisMolecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor MicroenvironmentToll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisLifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redoxCheminformatics Research at the Unilever Centre for Molecular Science Informatics CambridgeTumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in CancerUnfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancerMolecular mechanisms of human IRE1 activation through dimerization and ligand bindingSynthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway.Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation.JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.Endoplasmic reticulum stress and cancer.The transcription factor XBP1 is selectively required for eosinophil differentiation.Chemical induction of unfolded protein response enhances cancer cell killing through lytic virus infection.Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory load.Phosphoregulation of Ire1 RNase splicing activity.IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Quercetin affects Hsp70/IRE1α mediated protection from death induced by endoplasmic reticulum stress.Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum StressVirulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial CellsIncorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.
P2860
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P2860
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The molecular basis for select ...... an IRE1-binding small molecule
@ast
The molecular basis for select ...... an IRE1-binding small molecule
@en
The molecular basis for select ...... an IRE1-binding small molecule
@nl
type
label
The molecular basis for select ...... an IRE1-binding small molecule
@ast
The molecular basis for select ...... an IRE1-binding small molecule
@en
The molecular basis for select ...... an IRE1-binding small molecule
@nl
prefLabel
The molecular basis for select ...... an IRE1-binding small molecule
@ast
The molecular basis for select ...... an IRE1-binding small molecule
@en
The molecular basis for select ...... an IRE1-binding small molecule
@nl
P2093
P2860
P50
P3181
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P1476
The molecular basis for select ...... an IRE1-binding small molecule
@en
P2093
Benedict C S Cross
Jaroslav Zak
Pawel G Sadowski
Thomas A Neubert
P2860
P304
P3181
P356
10.1073/PNAS.1115623109
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P50
P577
2012-04-10T00:00:00Z