The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule - Test2 - elhamkhani - TriplyDB

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

http://www.wikidata.org/entity/Q24596804

about

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment The unfolded protein response in neurodegenerative diseases: a neuropathological perspective Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly Drugging the unfolded protein response in acute leukemias Protein homeostasis as a therapeutic target for diseases of protein conformation Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors Toll-like receptors in the pathogenesis of autoimmune diseases: recent and emerging translational developments Novel therapeutic strategies for multiple myeloma Tumor progression and the different faces of the PERK kinase Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox Cheminformatics Research at the Unilever Centre for Molecular Science Informatics Cambridge Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer Molecular mechanisms of human IRE1 activation through dimerization and ligand binding Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway.Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation.JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.Endoplasmic reticulum stress and cancer.The transcription factor XBP1 is selectively required for eosinophil differentiation.Chemical induction of unfolded protein response enhances cancer cell killing through lytic virus infection.Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory load.Phosphoregulation of Ire1 RNase splicing activity.IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1 Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Quercetin affects Hsp70/IRE1α mediated protection from death induced by endoplasmic reticulum stress.Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.

P2860

Q24301555-9531BF74-F553-46F9-BA42-F9AC9ED921B0 Q24339464-798681BB-42F3-477E-ABDA-05A0A3F15ECE Q24606387-34BE4AC4-9283-4144-910B-CB9C55656FBD Q26771256-1124657A-C1AB-4878-B536-E4FAE92B30AB Q26776377-27516A6D-5FD6-4E14-BD34-44A3C3C3E54A Q26799511-571DC654-FA7D-4E30-AFBA-7EFE9628830E Q26799567-394C20E3-E9F6-4534-BE2D-12D8AFD0F2B5 Q26801114-25B59B48-A47B-494A-B558-F6A6B76CC1F3 Q27003283-29262EF8-89AD-4971-B155-A5492CB570EE Q27640568-E90409A3-DB85-4019-9F6C-0997E35B16BA Q28067211-A1E399DB-A111-400C-B410-A3AF923C4974 Q28081590-286BAC84-113C-422E-ADD6-884E8E06ABAA Q28087036-ADA45443-9368-4E1E-A31F-C509AF13C82D Q28385517-2D060906-973F-4B94-9D88-519A70C180E6 Q28393599-58C9AD02-8750-4755-9FF0-66C90DA1DAE7 Q28589300-514FF827-7808-49DF-B8B1-7C452B762A56 Q28591111-5EDEADF9-960B-436C-8E55-906C67637DE5 Q28607245-1D0E9F87-2B81-4747-959C-F78F4AA3DC26 Q29248711-19773A28-861C-47ED-B28B-06816EE85225 Q29248716-F657EEC6-382C-4974-B3CB-91994E2F3A49 Q30404387-EFDC0907-5D71-4190-A20F-A0DDE58EDEA1 Q33654550-756EE08F-D930-41CB-8709-7438E4ED3936 Q33726281-D39983D3-1BB2-4C12-86B9-FF4451A0AA2F Q33831578-47A0CAE0-9214-4BAF-90D2-F97597175089 Q33858456-C5DDD9A5-7A14-4B8A-B692-3C23885727BB Q34376123-71AA06C6-F145-4187-8519-148C322F7AAF Q34483620-46DC343F-FDB9-4F2A-9761-C5DD970A5B5E Q34594638-1169AC4A-C5E1-4286-B64B-34414A53579D Q34701285-6B2B1DF5-3A10-470A-9882-2D3EA5ADED6F Q34756838-A16079B4-E0F9-4B89-A1CA-EC97AF9E4D1C Q35010090-1C6128AB-D347-4017-B2EF-6E509703789C Q35139989-C37A0DBF-7761-4A54-B474-9ABC9B1D89A5 Q35204732-4EC2080E-DDFD-4C77-BDF1-44733890FDB1 Q35227866-7A815D20-6A06-42CE-B95B-DD5C68C82954 Q35408665-3100630F-DA62-4E0F-BC94-8B8EDB605BCA Q35438034-F531B22E-FA82-46BC-A173-DDD60408186A Q35626096-ADD1CC9A-6168-48DC-88B2-83841555A754 Q35665882-DC2239F4-207F-4929-981C-D2E8CFFA91C7 Q35731654-A9BE13C4-EAAE-4838-BA9F-7326EEABE292 Q35743424-8AEBDF0F-AC74-4A85-89B0-B2A119C35272

P2860

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

http://www.wikidata.org/entity/Q24596804

description

2012 nî lūn-bûn

@nan

2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

The molecular basis for select ...... an IRE1-binding small molecule

@ast

The molecular basis for select ...... an IRE1-binding small molecule

@en

The molecular basis for select ...... an IRE1-binding small molecule

@nl

type

label

The molecular basis for select ...... an IRE1-binding small molecule

@ast

The molecular basis for select ...... an IRE1-binding small molecule

@en

The molecular basis for select ...... an IRE1-binding small molecule

@nl

prefLabel

The molecular basis for select ...... an IRE1-binding small molecule

@ast

The molecular basis for select ...... an IRE1-binding small molecule

@en

The molecular basis for select ...... an IRE1-binding small molecule

@nl

P1433

Q24596804-1A17D7FC-B1B6-4F63-B980-7C2FD4AAE6FE

P1476

Q24596804-761DAB6E-0EA4-42F7-B0B6-9833BE64A0F3

P2093

Q24596804-1CF03251-5054-4ACC-9B9E-F546FF876969

Q24596804-647FEF75-7285-4811-B4AF-F56EFA20FCFB

Q24596804-919F101B-FB82-49BC-994D-C09366E5ADDE

Q24596804-E2C4698D-36A8-4B49-8617-E68338CF2D1A

P2860

Q24596804-022AC2DA-FD4A-47B2-813D-4E3F42289B83

Q24596804-0547BA0B-8381-4BD2-BE36-7E2DC45AD61C

Q24596804-06504526-A2FF-4B70-A9CE-8D04F733C032

Q24596804-08749874-999D-452D-8E53-472312C260D6

Q24596804-0A4EFC81-BCB7-4853-9E59-265AD4FED28D

Q24596804-0D3FB934-2A58-4ACD-9D24-CB2D10180CBE

Q24596804-0DF578B6-1062-4047-A3C2-46E2E82F6397

Q24596804-16590667-2A4A-4B1F-B654-7502BD32B817

Q24596804-24F3249A-7373-4557-AD2A-AFFD342DC356

Q24596804-2A95D1EB-F384-4879-8590-8448335E0893

P304

Q24596804-667AB0AA-A1EB-474D-A783-C6A040D01B0B

P31

Q24596804-FA2532CF-1D8F-4837-B7B1-EB82D4DA7DA7

P3181

Q24596804-EEECE00B-E843-48CC-B206-AC4C4E8FA71A

P356

Q24596804-3C253138-3CD5-4E79-91C4-4F4629242841

P407

Q24596804-4AC7803A-7C76-417F-8DBC-55344B6E6712

P433

Q24596804-31AFF0EE-3AB4-406B-A916-BC4FDDC95872

P478

Q24596804-623AF278-AED9-45EA-A58A-E8FDC77CF68F

P50

Q24596804-010750BC-6BAA-495B-AF4C-B7D50023730F

Q24596804-064AC0DC-AC15-46F6-9546-C6C7688B3943

Q24596804-3A1720D4-6589-477D-9B1F-F8E59FB0D3BF

Q24596804-7FABC5FD-56D4-48AB-897A-2E7F5CA4F63E

Q24596804-99340032-791C-4534-8A3A-F8C5D5D3DD80

Q24596804-B664FC9D-BE79-44CD-9195-7C85F3941EC5

Q24596804-BEF9AB11-877B-44BC-98A3-E7EAE69746C6

P577

Q24596804-BE32369B-467F-4BE7-95BB-37681A713DE5

P5875

Q24596804-063B1C8A-9F06-469B-AB27-7BECA56B60E3

P698

Q24596804-4F57DB04-885B-4F09-B721-402467036808

P932

Q24596804-E6E4D74C-85C8-49B2-A230-437BBA32253A

P3181

P356

PNAS.1115623109

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

The molecular basis for select ...... an IRE1-binding small molecule

@en

P2093

Benedict C S Cross

http://www.w3.org/2001/XMLSchema#string

Jaroslav Zak

http://www.w3.org/2001/XMLSchema#string

Pawel G Sadowski

http://www.w3.org/2001/XMLSchema#string

Thomas A Neubert

http://www.w3.org/2001/XMLSchema#string

P2860

Plasma cell differentiation requires the transcription factor XBP-1

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

CHARMM: the biomolecular simulation program

Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.

Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum Stress

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

The unfolded protein response signals through high-order assembly of Ire1

P304

E869-78

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

37602

http://www.w3.org/2001/XMLSchema#string

P356

10.1073/PNAS.1115623109

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

109

http://www.w3.org/2001/XMLSchema#string

P50

Ian R. Baxendale

Jonathan M. Goodman

Heather P Harding

Robert H. Silverman

P577

2012-04-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221815569

http://www.w3.org/2001/XMLSchema#string

P698

22315414

http://www.w3.org/2001/XMLSchema#string

P932

3326519

http://www.w3.org/2001/XMLSchema#string