Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
about
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcBThe molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeDivergent allosteric control of the IRE1α endoribonuclease using kinase inhibitorsDangER: protein ovERload. Targeting protein degradation to treat myelomaThe unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein foldingConserved and plant-unique strategies for overcoming endoplasmic reticulum stressThe unfolded protein response and diabetic retinopathyStructure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitorsCofactor-mediated conformational control in the bifunctional kinase/RNase Ire1The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaksNovel therapeutic strategies for multiple myelomaThe unfolded protein response in immunity and inflammationThe unfolded protein response: from stress pathway to homeostatic regulationMolecular mechanisms of human IRE1 activation through dimerization and ligand bindingUbiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway.Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.Direct association of unfolded proteins with mammalian ER stress sensor, IRE1βAllosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis.A novel role for protein kinase Kin2 in regulating HAC1 mRNA translocation, splicing, and translation.Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α.Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.Phosphoregulation of Ire1 RNase splicing activity.A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alphaStructural basis for regulation of RNA-binding proteins by phosphorylation.PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.Differences in Unfolded Protein Response Pathway Activation in the Lenses of Three Types of Cataracts.UPR Activation and the Down-Regulation of α-Crystallin in Human High Myopia-Related Cataract Lens Epithelium.A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusionThe structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase.Oligomerization of the transmembrane domain of IRE1α in SDS micelles.A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing.Structural Basis for the Non-catalytic Functions of Protein Kinases.A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapyIRE1: ER stress sensor and cell fate executor.ER-stress in Alzheimer's disease: turning the scale?RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting.Kinase inhibitors as potential agents in the treatment of multiple myeloma.
P2860
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P2860
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structure of the Ire1 autophos ...... the unfolded protein response
@ast
Structure of the Ire1 autophos ...... the unfolded protein response
@en
Structure of the Ire1 autophos ...... the unfolded protein response
@en-gb
Structure of the Ire1 autophos ...... the unfolded protein response
@nl
type
label
Structure of the Ire1 autophos ...... the unfolded protein response
@ast
Structure of the Ire1 autophos ...... the unfolded protein response
@en
Structure of the Ire1 autophos ...... the unfolded protein response
@en-gb
Structure of the Ire1 autophos ...... the unfolded protein response
@nl
prefLabel
Structure of the Ire1 autophos ...... the unfolded protein response
@ast
Structure of the Ire1 autophos ...... the unfolded protein response
@en
Structure of the Ire1 autophos ...... the unfolded protein response
@en-gb
Structure of the Ire1 autophos ...... the unfolded protein response
@nl
P2093
P2860
P921
P356
P1433
P1476
Structure of the Ire1 autophos ...... the unfolded protein response
@en
P2093
Anthea Hardcastle
Craig McAndrews
Emma L Davenport
Faith E Davies
Gareth J Morgan
Ian Collins
Laurence H Pearl
M Cris Silva-Santisteban
Martin G Rowlands
Maruf M U Ali
P2860
P304
P356
10.1038/EMBOJ.2011.18
P407
P577
2011-03-02T00:00:00Z