CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations - Test2 - elhamkhani - TriplyDB

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

http://www.wikidata.org/entity/Q24614590

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The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency.Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue Autosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate dehydrogenase type I disrupt nucleic acid binding Bateman domains and adenosine derivatives form a binding contract A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer IMP dehydrogenase: structure, mechanism, and inhibition.IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site Comparative genome analysis of "Candidatus Phytoplasma australiense" (subgroup tuf-Australia I; rp-A) and "Ca. Phytoplasma asteris" Strains OY-M and AY-WB Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100 Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain Natural history of S-adenosylmethionine-binding proteins Regulation of AMP-activated protein kinase by natural and synthetic activators AMPK as a potential anticancer target - friend or foe?AMP-activated protein kinase: a target for drugs both ancient and modern AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function AMPK: a cellular metabolic and redox sensor. A minireview AMPK: a target for drugs and natural products with effects on both diabetes and cancer Nutrient-sensing mechanisms across evolution Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5 Biochemical and Structural Characterization of a Novel Family of Cystathionine β-Synthase Domain Proteins Fused to a Zn Ribbon-Like Domain Structures and Functional Implications of an AMP-Binding Cystathionine β-Synthase Domain Protein from a Hyperthermophilic Archaeon A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthase Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae.Multiple Motif Scanning to identify methyltransferases from the yeast proteome.Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies CBS domains: structure, function, and pathology in human proteins AMP-activated kinase AMPK is expressed in boar spermatozoa and regulates motility Activation of AMPK by bitter melon triterpenoids involves CaMKKβ CcpN (YqzB), a novel regulator for CcpA-independent catabolite repression of Bacillus subtilis gluconeogenic genes An extended network of genomic maintenance in the archaeon Pyrococcus abyssi highlights unexpected associations between eucaryotic homologs

P2860

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P2860

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

http://www.wikidata.org/entity/Q24614590

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

@zh-hant

2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

CBS domains form energy-sensin ...... disrupted by disease mutations

@ast

CBS domains form energy-sensin ...... disrupted by disease mutations

@en

CBS domains form energy-sensin ...... disrupted by disease mutations

@nl

type

label

CBS domains form energy-sensin ...... disrupted by disease mutations

@ast

CBS domains form energy-sensin ...... disrupted by disease mutations

@en

CBS domains form energy-sensin ...... disrupted by disease mutations

@nl

prefLabel

CBS domains form energy-sensin ...... disrupted by disease mutations

@ast

CBS domains form energy-sensin ...... disrupted by disease mutations

@en

CBS domains form energy-sensin ...... disrupted by disease mutations

@nl

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Journal of Clinical Investigation

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CBS domains form energy-sensin ...... disrupted by disease mutations

@en

P2093

D Grahame Hardie

http://www.w3.org/2001/XMLSchema#string

David G Norman

http://www.w3.org/2001/XMLSchema#string

Gillian A Scullion

http://www.w3.org/2001/XMLSchema#string

Greg Stewart

http://www.w3.org/2001/XMLSchema#string

John W Scott

http://www.w3.org/2001/XMLSchema#string

Kevin A Green

http://www.w3.org/2001/XMLSchema#string

Miliea Anis

http://www.w3.org/2001/XMLSchema#string

Simon A Hawley

http://www.w3.org/2001/XMLSchema#string

P2860

Role of AMP-activated protein kinase in mechanism of metformin action

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

The regulation of AMP-activated protein kinase by phosphorylation

Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa.

Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

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274-84

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scholarly article

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3929994

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10.1172/JCI19874

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P433

2

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113

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2004-01-01T00:00:00Z

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14722619

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311435

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