Role of AMP-activated protein kinase in mechanism of metformin action - Test2 - elhamkhani - TriplyDB

Role of AMP-activated protein kinase in mechanism of metformin action

Role of AMP-activated protein kinase in mechanism of metformin action

http://www.wikidata.org/entity/Q22241898

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Insulin sensitizing effects of oligomannuronate-chromium (III) complexes in C2C12 skeletal muscle cells Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade Risk of cancer in diabetes: the effect of metformin Guidelines for the use and interpretation of assays for monitoring autophagy The blooming of the French lilac Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle The antidiabetic gutsy role of metformin uncovered?Repurposing metformin: an old drug with new tricks in its binding pockets Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Relationships between cancer and aging: a multilevel approach Molecular mechanism of action of metformin: old or new insights?Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions Effects of the novel mitochondrial protein mimitin in insulin-secreting cells Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity Blasts from the past A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation.AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway AMP-activated protein kinase, stress responses and cardiovascular diseases Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapy CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations The AMPK signalling pathway coordinates cell growth, autophagy and metabolism Metformin activates AMP kinase through inhibition of AMP deaminase The ancient drug salicylate directly activates AMP-activated protein kinase Up- and down-regulation of adiponectin expression and multimerization: mechanisms and therapeutic implication The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta

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Role of AMP-activated protein kinase in mechanism of metformin action

http://www.wikidata.org/entity/Q22241898

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2001 nî lūn-bûn

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2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Role of AMP-activated protein kinase in mechanism of metformin action

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Journal of Clinical Investigation

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Role of AMP-activated protein kinase in mechanism of metformin action

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P2093

David E. Moller

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Gaochao Zhou

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John Ventre

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Judy Fenyk-Melody

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Laurie J. Goodyear

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Margaret Wu

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Michael F. Hirshman

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Nicolas Musi

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Nobuharu Fujii

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Thomas Doebber

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P2860

Mechanism by which metformin reduces glucose production in type 2 diabetes

The AMP-activated protein kinase--fuel gauge of the mammalian cell?

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes.

The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms.

Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle.

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1167-1174

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538230

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10.1172/JCI13505

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11602624

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