about
Bivalent and co-operative binding of complement factor H to heparan sulfate and heparinRegulation of signaling events involved in the pathophysiology of neovascular AMDMechanisms of age-related macular degenerationβA3/A1-crystallin: more than a lens proteinProtection of retina by αB crystallin in sodium iodate induced retinal degenerationBmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degenerationTargeted deletion of Vegfa in adult mice induces vision lossTLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophyDetection of early age-related macular degeneration using novel functional parameters of the focal cone electroretinogram.Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization.Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degenerationROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium.Clinical applications of age-related macular degeneration genetics.DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways.A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina.AMD-associated genes encoding stress-activated MAPK pathway constituents are identified by interval-based enrichment analysisActivation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularizationIdentification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eyeT cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degenerationPerforming subretinal injections in rodents to deliver retinal pigment epithelium cells in suspensionGene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy.Development of gene therapy for treatment of age-related macular degeneration.Efficient derivation of retinal pigment epithelium cells from stem cells.Vascular endothelial growth factor antagonist therapy for retinopathy of prematurityPlasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration.Suppression of Laser-Induced Choroidal Neovascularization by the Oral Medicine Targeting Histamine Receptor H4 in Mice.Morphological and functional evaluation of an animal model for the retinal degeneration induced by N-methyl-N-nitrosourea.Cyclic intensive light exposure induces retinal lesions similar to age-related macular degeneration in APPswe/PS1 bigenic miceTNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activationHedgehog Signaling Components Are Expressed in Choroidal Neovascularization in Laser-induced Retinal LesionRetinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization.Inflammatory priming predisposes mice to age-related retinal degeneration.Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunctionInflammatory Cytokines Induce Expression of Chemokines by Human Retinal Cells: Role in Chemokine Receptor Mediated Age-related Macular DegenerationThe putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field.Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematuritySilibinin inhibits VEGF secretion and age-related macular degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway.Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.The retinal pigment epithelium as a gateway for monocyte trafficking into the eye.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Therapeutic targets in age-related macular disease
@ast
Therapeutic targets in age-related macular disease
@en
Therapeutic targets in age-related macular disease
@nl
type
label
Therapeutic targets in age-related macular disease
@ast
Therapeutic targets in age-related macular disease
@en
Therapeutic targets in age-related macular disease
@nl
prefLabel
Therapeutic targets in age-related macular disease
@ast
Therapeutic targets in age-related macular disease
@en
Therapeutic targets in age-related macular disease
@nl
P2860
P3181
P356
P1476
Therapeutic targets in age-related macular disease
@en
P2093
Alan C Bird
P2860
P304
P3181
P356
10.1172/JCI42437
P407
P577
2010-09-01T00:00:00Z