Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling - Test2 - elhamkhani - TriplyDB

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

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Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors Recombinant human melatonin receptor MT1 isolated in mixed detergents shows pharmacology similar to that in mammalian cell membranes mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation.Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia Methods used to study the oligomeric structure of G-protein-coupled receptors.The rhodopsin-transducin complex houses two distinct rhodopsin molecules Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Biological effects of eukaryotic recombinant plasmid pReceiver-M61-BAI-1 transfection on T24 cells and HUVECs.Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications.Glutamate, glutamate receptors, and downstream signaling pathways Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.GPCR: G protein complexes--the fundamental signaling assembly.Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications Membrane protein synthesis in cell-free systems: from bio-mimetic systems to bio-membranes.Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.Mapping HA-tagged protein at the surface of living cells by atomic force microscopy.Contribution of heteromerization to G protein-coupled receptor function.Organization and functions of mGlu and GABAB receptor complexes.Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics.N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization.Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery.Small-angle scattering gives direct structural information about a membrane protein inside a lipid environment.[G protein-coupled receptors in the spot light].Class C G protein-coupled receptors: reviving old couples with new partners.Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs.

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Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

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2012 nî lūn-bûn

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Distinct roles of metabotropic ...... ivation and G-protein coupling

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Proceedings of the National Academy of Sciences of the United States of America

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Distinct roles of metabotropic ...... ivation and G-protein coupling

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Bernard Mouillac

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Driss El Moustaine

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Etienne Doumazane

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Jean-Philippe Pin

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Pauline Scholler

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Rita Rahmeh

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Sébastien Granier

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P2860

Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling

Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

Different functional roles of T1R subunits in the heteromeric taste receptors

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

Transduction of receptor signals by beta-arrestins

Blue native PAGE

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

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