Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
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Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatmentStructure of class C GPCR metabotropic glutamate receptor 5 transmembrane domainTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsRecombinant human melatonin receptor MT1 isolated in mixed detergents shows pharmacology similar to that in mammalian cell membranesmGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in RatsG protein-coupled receptor heterocomplexes in neuropsychiatric disorders.Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation.Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationAllosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophreniaMethods used to study the oligomeric structure of G-protein-coupled receptors.The rhodopsin-transducin complex houses two distinct rhodopsin moleculesInhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Biological effects of eukaryotic recombinant plasmid pReceiver-M61-BAI-1 transfection on T24 cells and HUVECs.Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications.Glutamate, glutamate receptors, and downstream signaling pathwaysAgonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domainsNeurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.GPCR: G protein complexes--the fundamental signaling assembly.Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indicationsMembrane protein synthesis in cell-free systems: from bio-mimetic systems to bio-membranes.Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.Mapping HA-tagged protein at the surface of living cells by atomic force microscopy.Contribution of heteromerization to G protein-coupled receptor function.Organization and functions of mGlu and GABAB receptor complexes.Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics.N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization.Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery.Small-angle scattering gives direct structural information about a membrane protein inside a lipid environment.[G protein-coupled receptors in the spot light].Class C G protein-coupled receptors: reviving old couples with new partners.Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs.
P2860
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P2860
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Distinct roles of metabotropic ...... ivation and G-protein coupling
@ast
Distinct roles of metabotropic ...... ivation and G-protein coupling
@en
Distinct roles of metabotropic ...... ivation and G-protein coupling
@nl
type
label
Distinct roles of metabotropic ...... ivation and G-protein coupling
@ast
Distinct roles of metabotropic ...... ivation and G-protein coupling
@en
Distinct roles of metabotropic ...... ivation and G-protein coupling
@nl
prefLabel
Distinct roles of metabotropic ...... ivation and G-protein coupling
@ast
Distinct roles of metabotropic ...... ivation and G-protein coupling
@en
Distinct roles of metabotropic ...... ivation and G-protein coupling
@nl
P2093
P2860
P3181
P356
P1476
Distinct roles of metabotropic ...... ivation and G-protein coupling
@en
P2093
Bernard Mouillac
Driss El Moustaine
Etienne Doumazane
Jean-Louis Banères
Jean-Philippe Pin
Patrick Bron
Pauline Scholler
Philippe Rondard
Rita Rahmeh
Sébastien Granier
P2860
P304
P3181
P356
10.1073/PNAS.1205838109
P407
P577
2012-10-02T00:00:00Z