Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness
about
Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cellsLarge-scale filament formation inhibits the activity of CTP synthetaseOnly one isoform of Drosophila melanogaster CTP synthase forms the cytoophidiumCrystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targetsMechanisms of product feedback regulation and drug resistance in cytidine triphosphate synthetases from the structure of a CTP-inhibited complexPhosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylationStructural requirements for the activation of Escherichia coli CTP synthase by the allosteric effector GTP are stringent, but requirements for inhibition are laxPyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream formsBioinformatics and Drug Discovery.A plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis.Phosphorylation of human CTP synthetase 1 by protein kinase A: identification of Thr455 as a major site of phosphorylation.Synthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor.Drug discovery and development for neglected parasitic diseases.CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae.CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repairThe enigmatic cytoophidium: compartmentation of CTP synthase via filament formation.State of the art in African trypanosome drug discovery.DNA building blocks: keeping control of manufacture.Critical roles of CTP synthase N-terminal in cytoophidium assemblyAn Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Metabolic signatures of Besnoitia besnoiti-infected endothelial host cells and blockage of key metabolic pathways indicate high glycolytic and glutaminolytic needs of the parasite.Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP.Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase.Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding.Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.Human CTP synthase filament structure reveals the active enzyme conformation.Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.Glutamine deprivation initiates reversible assembly of mammalian rods and rings.Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5'-Triphosphate.Oligomerization status directs overall activity regulation of the Escherichia coli class Ia ribonucleotide reductase.Inspired by Nature: The 3-Halo-4,5-dihydroisoxazole Moiety as a Novel Molecular Warhead for the Design of Covalent Inhibitors.Fresh insights into the pyrimidine metabolism in the trypanosomatids.A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii.Novel lead compounds in pre-clinical development against African sleeping sickness
P2860
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P2860
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@ast
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@en
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@nl
type
label
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@ast
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@en
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@nl
prefLabel
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@ast
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@en
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@nl
P2093
P2860
P921
P356
P1476
Trypanosoma brucei CTP synthet ...... t of African sleeping sickness
@en
P2093
P2860
P304
P356
10.1073/PNAS.111139498
P407
P577
2001-05-22T00:00:00Z