about
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sicknessRnr4p, a novel ribonucleotide reductase small-subunit proteinCid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.Yeast Sml1, a protein inhibitor of ribonucleotide reductase.Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelityThe mutation spectrum in genomic late replication domains shapes mammalian GC contentYeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrationsElevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutantsBreak-induced replication is highly inaccurateMutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethalityGenome instability due to ribonucleotide incorporation into DNA.The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.DNA building blocks at the foundation of better survival.Lesion bypass by S. cerevisiae Pol ζ alone.H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelitydNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotypeS phase block following MEC1ATR inactivation occurs without severe dNTP depletion.Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNATelomere length homeostasis responds to changes in intracellular dNTP pools.Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.Heterozygous colon cancer-associated mutations of SAMHD1 have functional significanceMolecular basis of the essential s phase function of the rad53 checkpoint kinase.Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase.Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups.Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.dNTP pools determine fork progression and origin usage under replication stress.Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer.Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.A common telomeric gene silencing assay is affected by nucleotide metabolism.Corrigendum: Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.Pre-activation of the genome integrity checkpoint increases DNA damage toleranceRnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Andrei Chabes
@ast
Andrei Chabes
@en
Andrei Chabes
@es
type
label
Andrei Chabes
@ast
Andrei Chabes
@en
Andrei Chabes
@es
prefLabel
Andrei Chabes
@ast
Andrei Chabes
@en
Andrei Chabes
@es
P106
P108
P1153
6701827550
P21
P31
P496
0000-0003-1708-8259