The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity - Test2 - elhamkhani - TriplyDB

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

http://www.wikidata.org/entity/Q24630723

about

Secondary bile acids: an underrecognized cause of colon cancer Bile acids as endogenous etiologic agents in gastrointestinal cancer Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance The vitamin D-antimicrobial peptide pathway and its role in protection against infection Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors Bile acids: regulation of synthesis Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection Induction of bilirubin clearance by the constitutive androstane receptor (CAR)The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).Bile acids: emerging role in management of liver diseases Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer Biology of PXR: role in drug-hormone interactions Nuclear receptors in bone physiology and diseases Regulation of the cytosolic sulfotransferases by nuclear receptors Targeting xenobiotic receptors PXR and CAR in human diseases Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation Bile Acids Promote the Expression of Hepatitis C Virus in Replicon-Harboring Cells Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.A brief history of the discovery of PXR and CAR as xenobiotic receptors Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators Bile acid signaling in metabolic disease and drug therapy A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis The farnesoid X-receptor is an essential regulator of cholesterol homeostasis Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2 Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model What are nuclear receptor ligands?Pregnane X receptor and natural products: beyond drug-drug interactions Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts Novel functions of PXR in cardiometabolic disease.Role of nuclear receptor SHP in metabolism and cancer.

P2860

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P2860

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

http://www.wikidata.org/entity/Q24630723

description

2001 nî lūn-bûn

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2001 թուականի Մարտին հրատարակուած գիտական յօդուած

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The nuclear receptor PXR is a ...... rotects against liver toxicity

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The nuclear receptor PXR is a ...... rotects against liver toxicity

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The nuclear receptor PXR is a ...... rotects against liver toxicity

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Proceedings of the National Academy of Sciences of the United States of America

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A LaTour

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B Goodwin

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B H Koller

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C D Klaassen

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D Hawkins-Brown

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J L Staudinger

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J Reinhard

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K I MacKenzie

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K K Brown

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S A Jones

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P2860

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

Identification of a nuclear receptor for bile acids

Bile acids: natural ligands for an orphan nuclear receptor

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

Regulation of bile acid synthesis

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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3369-74

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3943054

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10.1073/PNAS.051551698

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6

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98

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11248085

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30660

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