The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
about
Secondary bile acids: an underrecognized cause of colon cancerBile acids as endogenous etiologic agents in gastrointestinal cancerPossible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalaciaIdentification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearanceThe vitamin D-antimicrobial peptide pathway and its role in protection against infectionReduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alphaPerfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factorsBile acids: regulation of synthesisLigand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selectionInduction of bilirubin clearance by the constitutive androstane receptor (CAR)The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammalsHighly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).Bile acids: emerging role in management of liver diseasesBile Acid Metabolism and Signaling in Cholestasis, Inflammation, and CancerBiology of PXR: role in drug-hormone interactionsNuclear receptors in bone physiology and diseasesRegulation of the cytosolic sulfotransferases by nuclear receptorsTargeting xenobiotic receptors PXR and CAR in human diseasesSustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor ActivationBile Acids Promote the Expression of Hepatitis C Virus in Replicon-Harboring CellsCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.A brief history of the discovery of PXR and CAR as xenobiotic receptorsCrosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipidsTransgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicityThe farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashionIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesInhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivatorsBile acid signaling in metabolic disease and drug therapyA PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrileAlleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitisThe farnesoid X-receptor is an essential regulator of cholesterol homeostasisEvolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid PartnershipObstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver developmentDisturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse modelWhat are nuclear receptor ligands?Pregnane X receptor and natural products: beyond drug-drug interactionsEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsNovel functions of PXR in cardiometabolic disease.Role of nuclear receptor SHP in metabolism and cancer.
P2860
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P2860
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The nuclear receptor PXR is a ...... rotects against liver toxicity
@ast
The nuclear receptor PXR is a ...... rotects against liver toxicity
@en
The nuclear receptor PXR is a ...... rotects against liver toxicity
@nl
type
label
The nuclear receptor PXR is a ...... rotects against liver toxicity
@ast
The nuclear receptor PXR is a ...... rotects against liver toxicity
@en
The nuclear receptor PXR is a ...... rotects against liver toxicity
@nl
prefLabel
The nuclear receptor PXR is a ...... rotects against liver toxicity
@ast
The nuclear receptor PXR is a ...... rotects against liver toxicity
@en
The nuclear receptor PXR is a ...... rotects against liver toxicity
@nl
P2093
P2860
P3181
P356
P1476
The nuclear receptor PXR is a ...... rotects against liver toxicity
@en
P2093
B H Koller
C D Klaassen
D Hawkins-Brown
J L Staudinger
J Reinhard
K I MacKenzie
P2860
P304
P3181
P356
10.1073/PNAS.051551698
P407
P577
2001-03-13T00:00:00Z