SXR, a novel steroid and xenobiotic-sensing nuclear receptor
about
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CARThe xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARIdentification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearanceThe nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicityReduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alphaAlternatively spliced isoforms of the human constitutive androstane receptorSt. John's wort induces hepatic drug metabolism through activation of the pregnane X receptorControl of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptorPyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytesHighly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.Retinoid-xenobiotic interactions: the Ying and the YangNuclear Receptors, RXR, and the Big BangRole of pregnane X receptor in chemotherapeutic treatmentNuclear receptors in bone physiology and diseasesModulation of xenobiotic receptors by steroidsMarine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compoundsDual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cellsCrystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonismStructural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRαA brief history of the discovery of PXR and CAR as xenobiotic receptorsPregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsNuclear receptor response elements mediate induction of intestinal MDR1 by rifampinIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesHuman pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activityReverse yeast two-hybrid system to identify mammalian nuclear receptor residues that interact with ligands and/or antagonistsXenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR betaInduction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell lineOrphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligandsOptimization of stress response through the nuclear receptor-mediated cortisol signalling networkChallenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXRAlleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitisTranscriptional regulation of mouse PXR gene: an interplay of transregulatory factorsGenome-wide discovery of drug-dependent human liver regulatory elementsPregnane X receptor knockout mice display aging-dependent wearing of articular cartilageUp-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 CellsTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationAlterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactions
P2860
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P2860
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@ast
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@en
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@en-gb
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@nl
type
label
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@ast
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@en
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@en-gb
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@nl
prefLabel
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@ast
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@en
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@en-gb
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@nl
P2093
P2860
P3181
P356
P1433
P1476
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
@en
P2093
P2860
P304
P3181
P356
10.1101/GAD.12.20.3195
P407
P577
1998-10-01T00:00:00Z