HDAC4 regulates neuronal survival in normal and diseased retinas - Test2 - elhamkhani - TriplyDB

HDAC4 regulates neuronal survival in normal and diseased retinas

HDAC4 regulates neuronal survival in normal and diseased retinas

http://www.wikidata.org/entity/Q24631789

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A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo Histone deacetylase inhibitors: Potential in cancer therapy Histone Deacetylases Exert Class-Specific Roles in Conditioning the Brain and Heart Against Acute Ischemic Injury HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development Aberrant Expression of Histone Deacetylases 4 in Cognitive Disorders: Molecular Mechanisms and a Potential Target The promise and perils of HDAC inhibitors in neurodegeneration HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc Screening of selective histone deacetylase inhibitors by proteochemometric modeling.Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility.Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions.Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration The clinical development of histone deacetylase inhibitors as targeted anticancer drugs.HDAC4: mechanism of regulation and biological functions Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems.HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia.ATM and the epigenetics of the neuronal genome.Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse.Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy.HDAC4, a prognostic and chromosomal instability marker, refines the predictive value of MGMT promoter methylation.Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9 HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia.Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study.Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain.A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa.Epigenetic regulation of retinal development and disease.Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration.Suprachoroidal electrotransfer: a nonviral gene delivery method to transfect the choroid and the retina without detaching the retina.An essential role for histone deacetylase 4 in synaptic plasticity and memory formation Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.

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HDAC4 regulates neuronal survival in normal and diseased retinas

http://www.wikidata.org/entity/Q24631789

description

2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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type

label

HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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HDAC4 regulates neuronal survival in normal and diseased retinas

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Bo Chen

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Constance L Cepko

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P2860

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

Histone deacetylase 4 possesses intrinsic nuclear import and export signals

Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

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