RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA - Test2 - elhamkhani - TriplyDB

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

http://www.wikidata.org/entity/Q24632475

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More than 200 genes required for methane formation from H₂ and CO₂ and energy conservation are present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift Mechanistic and functional versatility of radical SAM enzymes Current chemical biology approaches to interrogate protein methyltransferases Radical SAM-mediated methylation reactions Radical-mediated enzymatic methylation: a tale of two SAMS Structural Basis for Methyl Transfer by a Radical SAM Enzyme Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex.Novel modifications in RNA Radical SAM enzymes in methylation and methylthiolation Emerging themes in radical SAM chemistry Identification of a unique radical S-adenosylmethionine methylase likely involved in methanopterin biosynthesis in Methanocaldococcus jannaschii.Paramagnetic intermediates generated by radical S-adenosylmethionine (SAM) enzymes The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.A radically different mechanism for S-adenosylmethionine-dependent methyltransferases.Uncovering the human methyltransferasome.Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism.Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance Profound methyl effects in drug discovery and a call for new C-H methylation reactions.Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Probing the reaction mechanism of spore photoproduct lyase (SPL) via diastereoselectively labeled dinucleotide SP TpT substrates.Low fitness cost of the multidrug resistance gene cfr.Complex biotransformations catalyzed by radical S-adenosylmethionine enzymes.Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence in Staphylococcus aureus.Mechanistic studies of the radical SAM enzyme spore photoproduct lyase (SPL).Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN.The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy.Mechanistic studies of the spore photoproduct lyase via a single cysteine mutation Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.Bacillithiol has a role in Fe-S cluster biogenesis in Staphylococcus aureus.Structural diversity in the AdoMet radical enzyme superfamily.Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase Radical SAM-dependent carbon insertion into the nitrogenase M-cluster Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Radical S-adenosylmethionine enzymes.

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P2860

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

http://www.wikidata.org/entity/Q24632475

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

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2010年论文

@wuu

name

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@ast

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@en

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@nl

type

label

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@ast

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@en

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@nl

prefLabel

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@ast

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@en

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@nl

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Journal of the American Chemical Society

P1476

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

@en

P2093

Alexander S Mankin

http://www.w3.org/2001/XMLSchema#string

Danica Galonić Fujimori

http://www.w3.org/2001/XMLSchema#string

Feng Yan

http://www.w3.org/2001/XMLSchema#string

Hassan Jomaa

http://www.w3.org/2001/XMLSchema#string

Jacqueline M LaMarre

http://www.w3.org/2001/XMLSchema#string

Jochen Wiesner

http://www.w3.org/2001/XMLSchema#string

Rene Röhrich

http://www.w3.org/2001/XMLSchema#string

P2860

Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

Biotin synthase contains two distinct iron-sulfur cluster binding sites: chemical and spectroelectrochemical analysis of iron-sulfur cluster interconversions

The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Methyltransferase That Modifies Guanine 966 of the 16 S rRNA: FUNCTIONAL IDENTIFICATION AND TERTIARY STRUCTURE

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3953-64

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scholarly article

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4315054

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P356

10.1021/JA910850Y

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P433

11

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132

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2010-03-24T00:00:00Z

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41577033

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20184321

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P921

rRNA (adenine-C2-)-methyltransferase activity

P932

2859901

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