The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.
about
Ribosome profiling: a Hi-Def monitor for protein synthesis at the genome-wide scaleEngine out of the chassis: cell-free protein synthesis and its usesRadical SAM-mediated methylation reactionsStructural Basis for Methyl Transfer by a Radical SAM EnzymeIdentification and Characterization of the Thermus thermophilus 5-Methylcytidine (m5C) Methyltransferase Modifying 23 S Ribosomal RNA (rRNA) Base C1942Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptideCharacterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmNThe proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complexCrystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNABiochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN MethyltransferasesAntibiotics: where to throw the spanner in the ribosomal machinery?Simulating the pulling of stalled elongated peptide from the ribosome by the translocon.Macrolide antibiotics allosterically predispose the ribosome for translation arrest.SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center.Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain.The arginine attenuator peptide interferes with the ribosome peptidyl transferase center.Sequence selectivity of macrolide-induced translational attenuationPicky nascent peptides do not talk to foreign ribosomes.Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistanceMechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Role of antibiotic ligand in nascent peptide-dependent ribosome stallingBirth, life and death of nascent polypeptide chains.Low fitness cost of the multidrug resistance gene cfr.Polytopic membrane protein folding at L17 in the ribosome tunnel initiates cyclical changes at the transloconCrucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function.A Nascent Peptide Signal Responsive to Endogenous Levels of Polyamines Acts to Stimulate Regulatory Frameshifting on Antizyme mRNAMechanisms of SecM-mediated stalling in the ribosomeResistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN.The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy.Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.Mechanisms of ribosome stalling by SecM at multiple elongation steps.Arginine changes the conformation of the arginine attenuator peptide relative to the ribosome tunnelNascent peptides that block protein synthesis in bacteria.Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.Regional discrimination and propagation of local rearrangements along the ribosomal exit tunnel.Tools for characterizing bacterial protein synthesis inhibitors.Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size.The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.
P2860
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P2860
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The key function of a conserve ...... sponse to the nascent peptide.
@ast
The key function of a conserve ...... sponse to the nascent peptide.
@en
The key function of a conserve ...... sponse to the nascent peptide.
@nl
type
label
The key function of a conserve ...... sponse to the nascent peptide.
@ast
The key function of a conserve ...... sponse to the nascent peptide.
@en
The key function of a conserve ...... sponse to the nascent peptide.
@nl
prefLabel
The key function of a conserve ...... sponse to the nascent peptide.
@ast
The key function of a conserve ...... sponse to the nascent peptide.
@en
The key function of a conserve ...... sponse to the nascent peptide.
@nl
P2093
P2860
P356
P1433
P1476
The key function of a conserve ...... sponse to the nascent peptide.
@en
P2093
Alexander S Mankin
Dorota Klepacki
Haripriya Ramu
Krishna Kannan
Nora Vázquez-Laslop
P2860
P304
P356
10.1038/EMBOJ.2010.180
P407
P577
2010-07-30T00:00:00Z