Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice - Test2 - elhamkhani - TriplyDB

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

http://www.wikidata.org/entity/Q24633423

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Pharmacological Targeting of the Hepcidin/Ferroportin Axis The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders Cancer cells with irons in the fire Hepcidin and iron homeostasis New insights into iron regulation and erythropoiesis The role of TMPRSS6/matriptase-2 in iron regulation and anemia Anemia: progress in molecular mechanisms and therapies Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches Hepcidin and iron regulation, 10 years later.β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies Identification of erythroferrone as an erythroid regulator of iron metabolism Iron regulation by hepcidin The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus Heme metabolism and erythropoiesis.Molecular liaisons between erythropoiesis and iron metabolism Identification of surrogates of protection against yersiniosis in immersion vaccinated Atlantic salmon A chemical screen identifies small molecules that regulate hepcidin expression.Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.Silencing airway epithelial cell-derived hepcidin exacerbates sepsis induced acute lung injury.Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait.Altered erythropoiesis and iron metabolism in carriers of thalassemia β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism.Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermedia Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload Superinfection in malaria: Plasmodium shows its iron will.Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome Reducing iron accumulation: A potential approach for the prevention and treatment of postmenopausal osteoporosis Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.Urine hepcidin has additive value in ruling out cardiopulmonary bypass-associated acute kidney injury: an observational cohort study.Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.Coordinate expression of heme and globin is essential for effective erythropoiesis Late stage erythroid precursor production is impaired in mice with chronic inflammation Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis.Do not super-excess me!

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P2860

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

http://www.wikidata.org/entity/Q24633423

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

@en

Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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type

label

Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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prefLabel

Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

@ast

Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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Journal of Clinical Investigation

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Hepcidin as a therapeutic tool ...... e anemia in β-thalassemic mice

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Cindy N Roy

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Eliezer A Rachmilewitz

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Elizabeta Nemeth

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Ella Guy

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Kristen Muirhead

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Luca Melchiori

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Maria Franca Marongiu

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Narla Mohandas

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Niva Rao

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Patricia J Giardina

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P2860

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Identification of a human heme exporter that is essential for erythropoiesis

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

Ineffective erythropoiesis and thalassemias

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure

Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia

A mouse model for beta 0-thalassemia

A heme export protein is required for red blood cell differentiation and iron homeostasis

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4466-4477

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scholarly article

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642867

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10.1172/JCI41717

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12

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120

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Stefano Rivella

Antonia Follenzi

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2010-11-22T00:00:00Z

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21099112

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2993583

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