Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.
about
The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranesLRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseCellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disordersMembrane curvature and its generation by BAR proteinsAlpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosisStructures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formationThe Synaptic Function of α-SynucleinMembrane remodeling and mechanics: Experiments and simulations of α-SynucleinAlpha-synuclein structure, functions, and interactionsNonenzymatic biomimetic remodeling of phospholipids in synthetic liposomesStructural insights into the cooperative remodeling of membranes by amphiphysin/BIN1.Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctionsHydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfacesMembrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption.Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR.Biophysics of α-synuclein membrane interactions.Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.α-Synuclein-induced tubule formation in lipid bilayersMolecular modeling of lipid membrane curvature induction by a peptide: more than simply shape.Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation.The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency.Synucleins regulate the kinetics of synaptic vesicle endocytosis.α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry.Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.Monomeric synucleins generate membrane curvature.Alpha-synuclein function and dysfunction on cellular membranes.Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.Determinants of adipophilin function in milk lipid formation and secretionDirect membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles.Molecular details of α-synuclein membrane association revealed by neutrons and photons.Membrane curvature sensing by amphipathic helices: a single liposome study using α-synuclein and annexin B12Tubulation by amphiphysin requires concentration-dependent switching from wedging to scaffolding.Biophysics of α-synuclein induced membrane remodellingDepth of α-synuclein in a bilayer determined by fluorescence, neutron reflectometry, and computation.α-synuclein, LRRK2 and their interplay in Parkinson's disease.Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes.α-Synuclein induces both positive mean curvature and negative Gaussian curvature in membranesImpact of N-terminal acetylation of α-synuclein on its random coil and lipid binding propertiesO-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease
P2860
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P2860
Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Membrane curvature induction a ...... synucleins and apolipoproteins
@nl
Membrane curvature induction a ...... ynucleins and apolipoproteins.
@ast
Membrane curvature induction a ...... ynucleins and apolipoproteins.
@en
type
label
Membrane curvature induction a ...... synucleins and apolipoproteins
@nl
Membrane curvature induction a ...... ynucleins and apolipoproteins.
@ast
Membrane curvature induction a ...... ynucleins and apolipoproteins.
@en
prefLabel
Membrane curvature induction a ...... synucleins and apolipoproteins
@nl
Membrane curvature induction a ...... ynucleins and apolipoproteins.
@ast
Membrane curvature induction a ...... ynucleins and apolipoproteins.
@en
P2093
P2860
P3181
P356
P1476
Membrane curvature induction a ...... ynucleins and apolipoproteins.
@en
P2093
Alasdair C Steven
Christine C Jao
Dimitrios G Stamou
Jitka Petrlova
Jobin Varkey
John C Voss
Jose Mario Isas
Martin Borch Jensen
Naoko Mizuno
Ralf Langen
P2860
P304
32486-32493
P3181
P356
10.1074/JBC.M110.139576
P407
P577
2010-08-06T00:00:00Z