Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization

Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization

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http://www.wikidata.org/entity/Q24634095
Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpressionThe dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteinsMutations in POMGNT1 cause non-syndromic retinitis pigmentosaCell specific post-translational processing of pikachurin, a protein involved in retinal synaptogenesisLARGE expression augments the glycosylation of glycoproteins in addition to α-dystroglycan conferring laminin binding.Differential glycosylation of α-dystroglycan and proteins other than α-dystroglycan by like-glycosyltransferaseFukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression.Adeno-associated viral-mediated LARGE gene therapy rescues the muscular dystrophic phenotype in mouse models of dystroglycanopathy.Biochemical and biophysical changes underlie the mechanisms of basement membrane disruptions in a mouse model of dystroglycanopathy.Lack of mGluR6-related cascade elements leads to retrograde trans-synaptic effects on rod photoreceptor synapses via matrix-associated proteins.Expression pattern in retinal photoreceptors of POMGnT1, a protein involved in muscle-eye-brain disease.Postnatal Gene Therapy Improves Spatial Learning Despite the Presence of Neuronal Ectopia in a Model of Neuronal Migration Disorder.Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies.Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.CNS synapses are stabilized trans-synaptically by laminins and laminin-interacting proteins.Second international workshop for glycosylation defects in muscular dystrophies, 11-12 November, 2010, Charlotte, USA.Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy.
P2860

Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization

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http://www.wikidata.org/entity/Q24634095
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2010 nî lūn-bûn
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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Post-translational maturation ...... d ribbon synaptic localization
@ast
Post-translational maturation ...... d ribbon synaptic localization
@en
Post-translational maturation ...... d ribbon synaptic localization
@nl
type
label
Post-translational maturation ...... d ribbon synaptic localization
@ast
Post-translational maturation ...... d ribbon synaptic localization
@en
Post-translational maturation ...... d ribbon synaptic localization
@nl
prefLabel
Post-translational maturation ...... d ribbon synaptic localization
@ast
Post-translational maturation ...... d ribbon synaptic localization
@en
Post-translational maturation ...... d ribbon synaptic localization
@nl
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P1476
P2093
P2860
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Post-translational maturation ...... d ribbon synaptic localization
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932