Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity
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Fukutin-related protein resides in the Golgi cisternae of skeletal muscle fibres and forms disulfide-linked homodimers via an N-terminal interactionWalker-Warburg syndromeDPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissuesISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndromeSGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan functionPikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpressionMouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophyPost-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localizationDeficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathiesGolgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilotPOMT2 mutations cause alpha-dystroglycan hypoglycosylation and Walker-Warburg syndromeThe potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophyMammalian O-mannosylation: unsolved questions of structure/functionN-glycans in cell survival and death: cross-talk between glycosyltransferasesA conserved acidic motif is crucial for enzymatic activity of protein O-mannosyltransferases.Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathiesAGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycanTargeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethalityExpression of the murine Pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of Walker-Warburg syndromeBrain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss.Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease.Cardiomyopathy in patients with POMT1-related congenital and limb-girdle muscular dystrophy.Fer kinase regulates cell migration through α-dystroglycan glycosylationGolgi UDP-GlcNAc:polypeptide O-α-N-Acetyl-d-glucosaminyltransferase 2 (TcOGNT2) regulates trypomastigote production and function in Trypanosoma cruzi.The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan.Construction of a library of human glycosyltransferases immobilized in the cell wall of Saccharomyces cerevisiae.Regulation of mammalian protein O-mannosylation: preferential amino acid sequence for O-mannose modification.Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX).Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscleThe dystroglycanopathies: the new disorders of O-linked glycosylationLarge induces functional glycans in an O-mannosylation dependent manner and targets GlcNAc terminals on alpha-dystroglycanMammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.Whoa man! Unexpected protein O-mannosylation pathways in mammalsLARGE expression augments the glycosylation of glycoproteins in addition to α-dystroglycan conferring laminin binding.Increased apoptosis of myoblasts in Drosophila model for the Walker-Warburg syndromeAdeno-associated virus-mediated overexpression of LARGE rescues α-dystroglycan function in dystrophic mice with mutations in the fukutin-related protein.
P2860
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P2860
Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Demonstration of mammalian pro ...... equired for enzymatic activity
@ast
Demonstration of mammalian pro ...... equired for enzymatic activity
@en
Demonstration of mammalian pro ...... equired for enzymatic activity
@en-gb
Demonstration of mammalian pro ...... equired for enzymatic activity
@nl
type
label
Demonstration of mammalian pro ...... equired for enzymatic activity
@ast
Demonstration of mammalian pro ...... equired for enzymatic activity
@en
Demonstration of mammalian pro ...... equired for enzymatic activity
@en-gb
Demonstration of mammalian pro ...... equired for enzymatic activity
@nl
prefLabel
Demonstration of mammalian pro ...... equired for enzymatic activity
@ast
Demonstration of mammalian pro ...... equired for enzymatic activity
@en
Demonstration of mammalian pro ...... equired for enzymatic activity
@en-gb
Demonstration of mammalian pro ...... equired for enzymatic activity
@nl
P2093
P2860
P3181
P356
P1476
Demonstration of mammalian pro ...... equired for enzymatic activity
@en
P2093
Aruto Yoshida
Atsuro Chiba
Hiroshi Manya
Richard U Margolis
Tamao Endo
Xiaohui Wang
Yasunori Chiba
Yoshifumi Jigami
P2860
P3181
P356
10.1073/PNAS.0307228101
P407
P577
2004-01-13T00:00:00Z