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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

http://www.wikidata.org/entity/Q24641822

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Transmissible Spongiform Encephalopathies Affecting Humans Prion hypothesis: the end of the controversy?The cellular prion protein PrPc is a partner of the Wnt pathway in intestinal epithelial cells Fatal prion disease in a mouse model of genetic E200K Creutzfeldt-Jakob disease Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism A brief history of prions Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases.Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein.High-resolution structure of infectious prion protein: the final frontier Single gene deletions of orexin, leptin, neuropeptide Y, and ghrelin do not appreciably alter food anticipatory activity in mice Cytosolic PrP can participate in prion-mediated toxicity Mouse models for studying the formation and propagation of prions.Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9.De novo prions.Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation.Prions.Review: contribution of transgenic models to understanding human prion disease.Characteristic CSF prion seeding efficiency in humans with prion diseases Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brain Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein.Striatal pathology underlies prion infection-mediated hyperactivity in mice.Requirements for mutant and wild-type prion protein misfolding in vitro.A new mechanism for transmissible prion diseases Interallelic Transcriptional Enhancement as an in Vivo Measure of Transvection in Drosophila melanogaster.Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins.Cellular prion protein: from physiology to pathology.Quantifying prion disease penetrance using large population control cohorts PrP(ST), a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease.Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies.Ethics in prion disease.Spontaneous generation of infectious prion disease in transgenic mice.Selective vulnerability to neurodegenerative disease: the curious case of Prion Protein.Prion protein misfolding, strains, and neurotoxicity: an update from studies on Mammalian prions.Design and construction of diverse mammalian prion strains Early structural features in mammalian prion conformation conversion.Review: membrane-associated misfolded protein propagation in natural transmissible spongiform encephalopathies (TSEs), synthetic prion diseases and Alzheimer's disease.From prion diseases to prion-like propagation mechanisms of neurodegenerative diseases.

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P2860

Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

http://www.wikidata.org/entity/Q24641822

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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J.NEURON.2009.07.026

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

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Alan Jasanoff

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Andrew D Steele

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Walker S Jackson

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Formation of native prions from minimal components in vitro

PrP knock-out and PrP transgenic mice in prion research

Mutations of the prion protein gene phenotypic spectrum

Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function

A general model of prion strains and their pathogenicity

Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers.

Neurological abnormalities in a knock-in mouse model of Huntington's disease

Novel proteinaceous infectious particles cause scrapie

The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases.

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Susan Lindquist

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Prion protein family

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