Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone
about
Local amplification of glucocorticoids in the aging brain and impaired spatial memorySequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degenerationThe bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndromeTumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7bCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitrocyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostateAdult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons5-Androstene-3β,7β,17β-triol (β-AET) slows thermal injury induced osteopenia in mice: relation to aging and osteoporosisRapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebratesThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functionsRegulation of cytochrome P450 (CYP) genes by nuclear receptors.Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation.Genetic connections between neurological disorders and cholesterol metabolismIdentification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA.Structural and dynamic basis of human cytochrome P450 7B1: a survey of substrate selectivity and major active site access channels.Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells.The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol.Drug-metabolizing cytochrome P450s in the brain.7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmonG protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition.Cytochromes p450: roles in diseasesBile Acid sulfation: a pathway of bile acid elimination and detoxification.Selection and evaluation of reference genes for analysis of mouse (Mus musculus) sex-dimorphic brain development.A role for CYP in the drug-hormone crosstalk of the brain.Niemann pick type C disease as a model for defects in neurosteroidogenesis.CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling.A new Thematic Series: genetics of human lipid diseases.Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A).From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans.Increased serum levels of dehydroepiandrosterone (DHEA) and interleukin-6 (IL-6) in women with mild to moderate Alzheimer's disease.Bioconversion of 3beta-hydroxy-5-cholenoic acid into chenodeoxycholic acid by rat brain enzyme systems.An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD.Neuroactive Steroids: Receptor Interactions and Responses.Neuroactive Steroids: Receptor Interactions and Responses.CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5.Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms.
P2860
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P2860
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@ast
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@en
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@nl
type
label
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@ast
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@en
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@nl
prefLabel
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@ast
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@en
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@nl
P2093
P2860
P50
P356
P1476
Cyp7b, a novel brain cytochrom ...... nd 7alpha-hydroxy pregnenolone
@en
P2093
G Stapleton
P2860
P304
P356
10.1073/PNAS.94.10.4925
P407
P577
1997-05-01T00:00:00Z