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Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of intronsThe bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasisCloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzymeCrystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brainTwo genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectivelyDo oxysterols control cholesterol homeostasis?Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenoloneHepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient miceSterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patientsBroad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brainPutative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cellsMechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasisDifferences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivoIdentification of new mutations in sterol 27-hydroxylase gene in Japanese patients with cerebrotendinous xanthomatosis (CTX)Novel homozygous and compound heterozygous mutations of sterol 27-hydroxylase gene (CYP27) cause cerebrotendinous xanthomatosis in three Japanese patients from two unrelated familiesSterol 27-hydroxylase in bile acid biosynthesis. Mechanism of oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,27-tetrol into 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acidExpression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modificationsCholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulationExpression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coliThe bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolaseMolecular cloning and expression of rabbit sterol 12alpha-hydroxylaseCholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retinaComparison of the proportion of unconjugated to total serum cholic acid and the [14C]-xylose breath test in patients with suspected small intestinal bacterial overgrowthAssay of 1,25-dihydroxy vitamin D3 by isotope dilution--mass fragmentographyThe plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in manRegulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patientsInfluence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenatesThe metabolism of steroids in the fatty liver induced by orotic acid feedingMechanism of intestinal 7 alpha-dehydroxylation of cholic acid: evidence that allo-deoxycholic acid is an inducible side-productA novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosisCerebrotendinous xanthomatosis: a defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acidAtherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophagesOxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophagesStudies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterolStudies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axesGeneration of viable cholesterol-free miceSulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice
P50
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P50
description
Zweeds onderzoeker
@nl
ollamh sa Karolinska Institutet
@ga
professor at Karolinska Institutet
@en
professor vid Karolinska Institutet
@sv
svensk professor
@nb
name
Ingemar Björkhem
@ast
Ingemar Björkhem
@da
Ingemar Björkhem
@de
Ingemar Björkhem
@en
Ingemar Björkhem
@es
Ingemar Björkhem
@fr
Ingemar Björkhem
@ga
Ingemar Björkhem
@nb
Ingemar Björkhem
@nl
Ingemar Björkhem
@nn
type
label
Ingemar Björkhem
@ast
Ingemar Björkhem
@da
Ingemar Björkhem
@de
Ingemar Björkhem
@en
Ingemar Björkhem
@es
Ingemar Björkhem
@fr
Ingemar Björkhem
@ga
Ingemar Björkhem
@nb
Ingemar Björkhem
@nl
Ingemar Björkhem
@nn
prefLabel
Ingemar Björkhem
@ast
Ingemar Björkhem
@da
Ingemar Björkhem
@de
Ingemar Björkhem
@en
Ingemar Björkhem
@es
Ingemar Björkhem
@fr
Ingemar Björkhem
@ga
Ingemar Björkhem
@nb
Ingemar Björkhem
@nl
Ingemar Björkhem
@nn
P1006
P1015
P214
P5587
P906
P1006
P1015
P106
P1153
36048740000
P21
P213
0000 0000 5462 6472
P214
P27
P31
P496
0000-0001-6087-9190
0000-0002-0575-9425
P5587
20dgg6zl264f586
P569
1941-04-25T00:00:00Z
P7859
viaf-19646628