K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum - Test2 - elhamkhani - TriplyDB

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

http://www.wikidata.org/entity/Q24645531

about

Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis 'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials BNP controls early load-dependent regulation of SERCA through calcineurin.Novel aspects of excitation-contraction coupling in heart failure.Targeting cardiomyocyte Ca2+ homeostasis in heart failure.JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy.Heart failure modulates electropharmacological characteristics of sinoatrial nodes.Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress Cardiac inotropes: current agents and future directions.Novel therapeutic targets for the treatment of heart failure.Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps.Ivabradine for the treatment of chronic heart failure.Calcium-mediated cellular triggered activity in atrial fibrillation.K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca(2+) release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes.Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?The contractile adaption to preload depends on the amount of afterload.Impact of RyR2 potentiation on myocardial function.Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts.

P2860

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P2860

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

http://www.wikidata.org/entity/Q24645531

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

K201 improves aspects of the c ...... rom the sarcoplasmic reticulum

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K201 improves aspects of the c ...... rom the sarcoplasmic reticulum

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K201 improves aspects of the c ...... rom the sarcoplasmic reticulum

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K201 improves aspects of the c ...... rom the sarcoplasmic reticulum

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K201 improves aspects of the c ...... rom the sarcoplasmic reticulum

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K201 improves aspects of the c ...... rom the sarcoplasmic reticulum

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Basic Research in Cardiology

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K201 improves aspects of the c ...... rom the sarcoplasmic reticulum

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Christopher M Loughrey

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Friedrich A Schöndube

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Gero Tenderich

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Godfrey L Smith

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Jan D Schmitto

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Karl Toischer

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Noboru Kaneko

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Reiner Körfer

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Stephan E Lehnart

http://www.w3.org/2001/XMLSchema#string

Tim Seidler

http://www.w3.org/2001/XMLSchema#string

P2860

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease.

Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle.

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure.

Novel targets for treating heart and muscle disease: stabilizing ryanodine receptors and preventing intracellular calcium leak.

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Hendrik Milting

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