Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. - Test2 - elhamkhani - TriplyDB

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

http://www.wikidata.org/entity/Q34270987

about

Calsequestrin 2 and arrhythmias In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum Molecular evolution of the junctophilin gene family Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis A network-oriented perspective on cardiac calcium signaling Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of -Adrenergic Receptor Signaling Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function.Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.Axial tubule junctions control rapid calcium signaling in atria Intermolecular failure of L-type Ca2+ channel and ryanodine receptor signaling in hypertrophy.Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts.Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease.Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors.Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats Cardiac ryanodine receptor phosphorylation: target sites and functional consequences Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.Mechanisms of Ca²+ handling in zebrafish ventricular myocytes β-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure.Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca(2+)-activated (BK) and ATP-sensitive (K ATP) K (+) channels.The ryanodine receptor in cardiac physiology and disease.Profile of Andrew R. Marks.ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation Ryanodine receptors as pharmacological targets for heart disease.Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart.

P2860

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P2860

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

http://www.wikidata.org/entity/Q34270987

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Ryanodine receptor/calcium rel ...... of heart failure progression.

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Ryanodine receptor/calcium rel ...... of heart failure progression.

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Ryanodine receptor/calcium rel ...... of heart failure progression.

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Ryanodine receptor/calcium rel ...... of heart failure progression.

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Ryanodine receptor/calcium rel ...... of heart failure progression.

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Ryanodine receptor/calcium rel ...... of heart failure progression.

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Ryanodine receptor/calcium rel ...... of heart failure progression.

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PNAS.0510113103

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Proceedings of the National Academy of Sciences of the United States of America

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Ryanodine receptor/calcium rel ...... of heart failure progression.

@en

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Andrew R Marks

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Anetta Wronska

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John A Vest

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Stephan E Lehnart

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Steven Reiken

http://www.w3.org/2001/XMLSchema#string

P2860

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes

Modulation of the Ca(2+)-induced Ca(2+) release cascade by beta-adrenergic stimulation in rat ventricular myocytes

Calcium signalling in cardiac muscle: refractoriness revealed by coherent activation.

Cardiac intracellular calcium release channels: role in heart failure.

Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites.

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10.1073/PNAS.0510113103

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3

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103

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Xander H T Wehrens

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7365156

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16407108

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phosphorylation

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1334677

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