Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations
about
Structure and function of an irreversible agonist-β(2) adrenoceptor complexMembrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulationsMolecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithmsCharting a Path to Success in Virtual ScreeningSmall Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of DynamicsDiversity and modularity of G protein-coupled receptor structuresInduced effects of sodium ions on dopaminergic G-protein coupled receptorsOne-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologueStructure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective AntagonistTwo distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptorHigh-resolution crystal structure of human protease-activated receptor 1Structure and dynamics of the M3 muscarinic acetylcholine receptorUnderstanding functional residues of the cannabinoid CB1.Equilibrium sampling in biomolecular simulationsUnderstanding the basis of a class of paradoxical mutations in AraC through simulationsMolecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes.Hierarchical domain-motion analysis of conformational changes in sarcoplasmic reticulum Ca²⁺-ATPase.The role of experimental and computational structural approaches in 7TM drug discovery.Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol.Showcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Structural heterogeneity of the μ-opioid receptor's conformational ensemble in the apo stateComparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptorInvestigations of α-helix↔β-sheet transition pathways in a miniprotein using the finite-temperature string methodStructure prediction of the second extracellular loop in G-protein-coupled receptorsIncreasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?Putative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics.A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptorDifferences in allosteric communication pipelines in the inactive and active states of a GPCR.Exploring atomic resolution physiology on a femtosecond to millisecond timescale using molecular dynamics simulationsProtein dynamics investigated by inherent structure analysis.Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach.Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.Structural insights into human GPCR protein OA1: a computational perspective.Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization propertiesAction of molecular switches in GPCRs--theoretical and experimental studies.Highly conserved tyrosine stabilizes the active state of rhodopsin.Probing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors.
P2860
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P2860
Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification of two distinct ...... l and biochemical observations
@ast
Identification of two distinct ...... l and biochemical observations
@en
Identification of two distinct ...... l and biochemical observations
@nl
type
label
Identification of two distinct ...... l and biochemical observations
@ast
Identification of two distinct ...... l and biochemical observations
@en
Identification of two distinct ...... l and biochemical observations
@nl
prefLabel
Identification of two distinct ...... l and biochemical observations
@ast
Identification of two distinct ...... l and biochemical observations
@en
Identification of two distinct ...... l and biochemical observations
@nl
P2093
P2860
P3181
P356
P1476
Identification of two distinct ...... l and biochemical observations
@en
P2093
Daniel H Arlow
David E Shaw
David W Borhani
Morten Ø Jensen
Ron O Dror
Stefano Piana
P2860
P304
P3181
P356
10.1073/PNAS.0811065106
P407
P577
2009-03-24T00:00:00Z