Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations - Test2 - elhamkhani - TriplyDB

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

http://www.wikidata.org/entity/Q24645752

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Structure and function of an irreversible agonist-β(2) adrenoceptor complex Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms Charting a Path to Success in Virtual Screening Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics Diversity and modularity of G protein-coupled receptor structures Induced effects of sodium ions on dopaminergic G-protein coupled receptors One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor High-resolution crystal structure of human protease-activated receptor 1 Structure and dynamics of the M3 muscarinic acetylcholine receptor Understanding functional residues of the cannabinoid CB1.Equilibrium sampling in biomolecular simulations Understanding the basis of a class of paradoxical mutations in AraC through simulations Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes.Hierarchical domain-motion analysis of conformational changes in sarcoplasmic reticulum Ca²⁺-ATPase.The role of experimental and computational structural approaches in 7TM drug discovery.Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol.Showcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Structural heterogeneity of the μ-opioid receptor's conformational ensemble in the apo state Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptor Investigations of α-helix↔β-sheet transition pathways in a miniprotein using the finite-temperature string method Structure prediction of the second extracellular loop in G-protein-coupled receptors Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?Putative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics.A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor Differences in allosteric communication pipelines in the inactive and active states of a GPCR.Exploring atomic resolution physiology on a femtosecond to millisecond timescale using molecular dynamics simulations Protein dynamics investigated by inherent structure analysis.Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach.Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.Structural insights into human GPCR protein OA1: a computational perspective.Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties Action of molecular switches in GPCRs--theoretical and experimental studies.Highly conserved tyrosine stabilizes the active state of rhodopsin.Probing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors.

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P2860

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

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Daniel H Arlow

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David E Shaw

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David W Borhani

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Morten Ø Jensen

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Ron O Dror

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Stefano Piana

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P2860

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

Crystal structure of rhodopsin: A G protein-coupled receptor

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

Structure of a beta1-adrenergic G-protein-coupled receptor.

Crystal structure of opsin in its G-protein-interacting conformation

All-atom empirical potential for molecular modeling and dynamics studies of proteins

VMD: visual molecular dynamics

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

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