Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor - Test2 - elhamkhani - TriplyDB

Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

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Diversity and modularity of G protein-coupled receptor structures Large-scale production and protein engineering of G protein-coupled receptors for structural studies New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulations Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state Biophysical Fragment Screening of the β 1 -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor 3D structure prediction of human β1-adrenergic receptor via threading-based homology modeling for implications in structure-based drug designing Compound activity prediction using models of binding pockets or ligand properties in 3D.Comparison of dynamics of extracellular accesses to the β(1) and β(2) adrenoceptors binding sites uncovers the potential of kinetic basis of antagonist selectivity.Structure-function of the G protein-coupled receptor superfamily.Leu128(3.43) (l128) and Val247(6.40) (V247) of CXCR1 are critical amino acid residues for g protein coupling and receptor activation.Allosteric sodium in class A GPCR signaling Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties Comparative analysis of the heptahelical transmembrane bundles of G protein-coupled receptors.Action of molecular switches in GPCRs--theoretical and experimental studies.Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1.Structural features of β2 adrenergic receptor: crystal structures and beyond.Characterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1.Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation.Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound β1-Adrenergic Receptor.Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening.Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptor How Can Mutations Thermostabilize G-Protein-Coupled Receptors?Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation The role of ligands on the equilibria between functional states of a G protein-coupled receptor.Lifting the lid on GPCRs: the role of extracellular loops.The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands.X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?Molecular modeling of vasopressin receptor and in silico screening of V1b receptor antagonists.Structural determinants of arrestin functions Structure-based and fragment-based GPCR drug discovery.

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P2860

Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

http://www.wikidata.org/entity/Q27667675

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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Two distinct conformations of ...... of a beta1-adrenergic receptor

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Andrew G W Leslie

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Maria J Serrano-Vega

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Patricia C Edwards

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Rouslan Moukhametzianov

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P2860

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

Crystal structure of rhodopsin: A G protein-coupled receptor

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

Crystal structure of the ligand-free G-protein-coupled receptor opsin

Structure of a beta1-adrenergic G-protein-coupled receptor.

Crystal structure of opsin in its G-protein-interacting conformation

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10.1073/PNAS.1100185108

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108

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Christopher G. Tate

Gebhard Schertler

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51096190

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21540331

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3100933

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