Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a - Test2 - elhamkhani - TriplyDB

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

http://www.wikidata.org/entity/Q24647566

about

Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197 Targeting RTK Signaling Pathways in Cancer MET inhibitors in combination with other therapies in non-small cell lung cancer MET: a critical player in tumorigenesis and therapeutic target c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations A crystallographic snapshot of tyrosine trans-phosphorylation in action Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases Contribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma Treatments Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.Sequence and structure signatures of cancer mutation hotspots in protein kinases Circulating tumor DNA profiling by next generation sequencing reveals heterogeneity of crizotinib resistance mechanisms in a gastric cancer patient with MET amplification.Cancer driver mutations in protein kinase genes Small molecule c-Met kinase inhibitors: a review of recent patents.Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening MET: a promising anticancer therapeutic target.A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors.Hepatocyte growth factor and Met in drug discovery.Acylated Iridoids and Rhamnopyranoses from Premna odorata (Lamiaceae) as Novel Mesenchymal-Epithelial Transition Factor Receptor Inhibitors for the Control of Breast Cancer.Pharmacophore Mapping Approach for Drug Target Identification: A Chemical Synthesis and in Silico Study on Novel Thiadiazole Compounds.Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers.Trends in the development of MET inhibitors for hepatocellular carcinoma.Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer Genetic predisposition to kidney cancer.Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain.Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase.A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.Identification of Phytochemicals Targeting c-Met Kinase Domain using Consensus Docking and Molecular Dynamics Simulation Studies.Overview of drug discovery and development.Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening.[Thirty years of Met receptor research: from the discovery of an oncogene to the development of targeted therapies].

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P2860

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

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2003 nî lūn-bûn

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2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Proceedings of the National Academy of Sciences of the United States of America

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Crystal structure of the tyros ...... the microbial alkaloid K-252a

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Jean Cui

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Luisa Rusconi

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Maria M Flocco

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Nikolaus Schiering

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Rita Perego

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P2860

Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis

Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

Crystal structure of the tyrosine kinase domain of the human insulin receptor

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22

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Cinzia Cristiani

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crystal structure

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