Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
about
Structure of the human protein kinase MPSK1 reveals an atypical activation loop architectureStructural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197Targeting RTK Signaling Pathways in CancerMET inhibitors in combination with other therapies in non-small cell lung cancerMET: a critical player in tumorigenesis and therapeutic targetc-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutationsA crystallographic snapshot of tyrosine trans-phosphorylation in actionCrystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitorStructural Basis for Selective Small Molecule Kinase Inhibition of Activated c-MetThe Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variantsIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesContribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma TreatmentsComputational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.Sequence and structure signatures of cancer mutation hotspots in protein kinasesCirculating tumor DNA profiling by next generation sequencing reveals heterogeneity of crizotinib resistance mechanisms in a gastric cancer patient with MET amplification.Cancer driver mutations in protein kinase genesSmall molecule c-Met kinase inhibitors: a review of recent patents.Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasionDirected discovery of agents targeting the Met tyrosine kinase domain by virtual screeningMET: a promising anticancer therapeutic target.A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors.Hepatocyte growth factor and Met in drug discovery.Acylated Iridoids and Rhamnopyranoses from Premna odorata (Lamiaceae) as Novel Mesenchymal-Epithelial Transition Factor Receptor Inhibitors for the Control of Breast Cancer.Pharmacophore Mapping Approach for Drug Target Identification: A Chemical Synthesis and in Silico Study on Novel Thiadiazole Compounds.Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers.Trends in the development of MET inhibitors for hepatocellular carcinoma.Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancerGenetic predisposition to kidney cancer.Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain.Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase.A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.Identification of Phytochemicals Targeting c-Met Kinase Domain using Consensus Docking and Molecular Dynamics Simulation Studies.Overview of drug discovery and development.Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening.[Thirty years of Met receptor research: from the discovery of an oncogene to the development of targeted therapies].
P2860
Q24306078-49123A71-42DC-4BA0-8867-0500FAB3351DQ24307789-1C76BBD8-F121-4169-B0CD-BD8512D24F14Q24608143-50C191AA-AA33-4F34-BDAE-4ABAC0D83D8BQ26781278-2B2C8E63-DA2C-4B5A-A99D-C4F3A47EA153Q26823203-A803209D-F20A-4B61-9B25-DF04E42E1AB7Q27008925-CA3E1F4E-E8F2-495A-AE17-275B581C5BACQ27649203-AB4AE376-55D7-4B9D-8727-7172C6BD2DBCQ27653072-DDFE85BB-A863-4992-9E3A-0CDCD44F35F3Q27653589-510E5134-1737-4638-9299-0BBB2169F9B4Q27666642-E769654D-57D1-4169-A921-581689053AF4Q28254690-40AA4D5A-EE2A-41D9-9047-6BFD3B5A7164Q28270556-340A9B76-20F6-4A32-9769-EADB1129E086Q28547357-4ABE193E-DA69-4081-B5DA-EE54461C885FQ30374663-19ED0FE9-0526-4536-874D-D4921E61231DQ33510934-9EFC97F0-D112-48DE-B26D-92A2F4E08B6CQ33688625-27D66B27-0A37-4C6E-822C-2BA40F3183AAQ34002709-A282683D-D16B-4B9E-9FC9-3277353D020EQ34094632-B3EE9391-77AA-466B-80B0-B36372A4B2E3Q34583547-C4E36A10-90CC-4061-A815-F97F50716313Q36012247-1C0BC40B-CCF0-432D-B589-9360E8B2BE8AQ36437161-CA1D4786-EB4F-4FFD-967D-1829A4EAA0A7Q37231567-1485C80F-36D3-4BEC-9E12-35CEC7B5FAA4Q38008247-612AB69A-C4B7-4185-813F-647ABBA59A1BQ38304282-3D5579E2-FDB6-4041-BC15-6E9A955F252AQ38377273-946CAE29-743A-445C-B790-A9E5C296DBC7Q38642364-06B6DF56-98A2-4E8C-B859-C3FA14554AD0Q38704262-E86E91E5-BCDB-41E5-9E58-55D90E6ACFE3Q38735120-F51A9369-6B95-4BC8-AD21-9C4F526BF9E6Q38777675-1142F9D2-4006-4F2C-8317-53AB42204FD4Q38858554-32D361FB-1E99-4A6B-A61B-23C54AA3A1E7Q39023793-A24BB255-DC96-468D-817E-BE5EC3C0B3D5Q39628474-E4B2C1B6-65BA-4C02-A7EA-288043CDF85AQ40384638-9C36D4D4-D79C-4A5D-9641-B38092DC4FD1Q45126637-1C3A8605-1F2F-455A-AA51-514694B5E19CQ47885052-638656F6-4378-49BC-80AB-448F22955BAAQ48597867-3180A398-395F-4999-B567-BB41AE44D043Q51610986-C304FCED-0A04-407A-9BA4-4625AE5AFFD8Q55070676-C39B1B20-0E61-402B-A116-89F68A2541DC
P2860
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@ast
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@en
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@nl
type
label
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@ast
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@en
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@nl
prefLabel
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@ast
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@en
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@nl
P2093
P2860
P356
P1476
Crystal structure of the tyros ...... the microbial alkaloid K-252a
@en
P2093
Luisa Rusconi
Maria M Flocco
Marina Marconi
Nikolaus Schiering
Rita Perego
P2860
P304
P356
10.1073/PNAS.1734128100
P407
P577
2003-10-28T00:00:00Z