Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.
about
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutationsStructural Basis for Selective Small Molecule Kinase Inhibition of Activated c-MetAssessing the range of kinase autoinhibition mechanisms in the insulin receptor familyLY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft modelsStructural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase DomainX-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitorsAbl kinase constructs expressed in bacteria: facilitation of structural and functional studies including segmental labeling by expressed protein ligationComputational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.Sequence and structure signatures of cancer mutation hotspots in protein kinasesCirculating tumor DNA profiling by next generation sequencing reveals heterogeneity of crizotinib resistance mechanisms in a gastric cancer patient with MET amplification.Cancer driver mutations in protein kinase genesCatalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.Bioinformatics and variability in drug response: a protein structural perspective.The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasionThe insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Receptor tyrosine kinases: mechanisms of activation and signaling.Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activationStrategies to optimize protein expression in E. coli.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.Hepatocyte growth factor and Met in drug discovery.Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.Pharmacophore Mapping Approach for Drug Target Identification: A Chemical Synthesis and in Silico Study on Novel Thiadiazole Compounds.Phosphorylation State-Dependent High Throughput Screening of the c-Met Kinase.Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.Production of Protein Kinases in E. coli.High-throughput structural characterisation of therapeutic protein targets
P2860
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P2860
Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structural characterization of ...... n in bacteria with phosphatase
@nl
Structural characterization of ...... in bacteria with phosphatase.
@ast
Structural characterization of ...... in bacteria with phosphatase.
@en
Structural characterization of ...... in bacteria with phosphatase.
@en-gb
type
label
Structural characterization of ...... n in bacteria with phosphatase
@nl
Structural characterization of ...... in bacteria with phosphatase.
@ast
Structural characterization of ...... in bacteria with phosphatase.
@en
Structural characterization of ...... in bacteria with phosphatase.
@en-gb
prefLabel
Structural characterization of ...... n in bacteria with phosphatase
@nl
Structural characterization of ...... in bacteria with phosphatase.
@ast
Structural characterization of ...... in bacteria with phosphatase.
@en
Structural characterization of ...... in bacteria with phosphatase.
@en-gb
P2093
P2860
P356
P1476
Structural characterization of ...... in bacteria with phosphatase.
@en
P2093
Abhinav Kumar
Adhirai Marimuthu
Ben Powell
Brian L West
Catherine Luu
Heike I Krupka
Hoa Nguyen
James Tsai
Maryam Tabrizizad
Weiru Wang
P2860
P304
P356
10.1073/PNAS.0600048103
P407
P577
2006-02-28T00:00:00Z