Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway - Test2 - elhamkhani - TriplyDB

Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway

Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway

http://www.wikidata.org/entity/Q24648040

about

The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment The role of mTOR signaling in Alzheimer disease Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome Roles of tau protein in health and disease.The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons.A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca(2+) CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY.Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR signaling Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide.Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease.Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo.Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons Neuritic complexity of hippocampal neurons depends on WIP-mediated mTORC1 and Abl family kinases activities Cyr61, a matricellular protein, is needed for dendritic arborization of hippocampal neurons.The importance of tau phosphorylation for neurodegenerative diseases Rapamycin, Autophagy, and Alzheimer's Disease Targeted treatment trials for tuberous sclerosis and autism: no longer a dream.mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors.Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization.The DPYSL2 gene connects mTOR and schizophrenia.GSK3 signalling in neural development.Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex.TSC1/TSC2 signaling in the CNS.Translational research: Rett syndrome and tuberous sclerosis complex.Role of GSK3 Signaling in Neuronal Morphogenesis.Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?Biochemistry and cell biology of tau protein in neurofibrillary degeneration Insulin in the brain: sources, localization and functions.Targeting the mTOR signaling network for Alzheimer's disease therapy.Tau-dependent suppression of adult neurogenesis in the stressed hippocampus.

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Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway

http://www.wikidata.org/entity/Q24648040

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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type

label

Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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prefLabel

Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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JBC.M109.008177

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Journal of Biological Chemistry

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Specification of neuronal pola ...... au via the mTOR-p70S6K pathway

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Kenji Sobue

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Tsuyoshi Morita

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P2860

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

Rheb and mTOR regulate neuronal polarity through Rap1B

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Upstream and downstream of mTOR

Tubulin and CRMP-2 complex is transported via Kinesin-1

Tuberous sclerosis complex proteins control axon formation

The establishment of polarity by hippocampal neurons in culture

The distribution of tau in the mammalian central nervous system

Biochemical and immunological analyses of cytoskeletal domains of neurons

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