Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K
about
Signaling by target of rapamycin proteins in cell growth controlBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthSpecification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathwayRegulation of mTORC1 by PI3K signalingThe tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stressesTOR signaling.Cell growth control: little eukaryotes make big contributions.Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in DrosophilaSirolimus therapy following early cyclosporine withdrawal in transplant patients: mechanisms of action and clinical results.Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.Targeting protein prenylation for cancer therapyRecent progress in the study of the Rheb family GTPases.Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) acLipid posttranslational modifications. Farnesyl transferase inhibitors.Rheb1 is required for mTORC1 and myelination in postnatal brain developmentPhospholipase D1 is an effector of Rheb in the mTOR pathway.The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.The molecular machinery of autophagy: unanswered questions.TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.Mouse models of tuberous sclerosis complex.mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer.Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosisThe mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting.mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused.Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.Dominant-negative proteins in herpesviruses - from assigning gene function to intracellular immunization.Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).Therapeutic strategies for targeting ras proteins.Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif.Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast.The switch I region of Rheb is critical for its interaction with FKBP38.Lymphangioleiomyomatosis: A Monogenic Model of Malignancy.Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth.Effects of RhebL1 silencing on the mTOR pathway.Rheb G-Proteins and the Activation of mTORC1.
P2860
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P2860
Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Identification of dominant neg ...... eb in the activation of p70S6K
@ast
Identification of dominant neg ...... eb in the activation of p70S6K
@en
Identification of dominant neg ...... eb in the activation of p70S6K
@en-gb
Identification of dominant neg ...... eb in the activation of p70S6K
@nl
type
label
Identification of dominant neg ...... eb in the activation of p70S6K
@ast
Identification of dominant neg ...... eb in the activation of p70S6K
@en
Identification of dominant neg ...... eb in the activation of p70S6K
@en-gb
Identification of dominant neg ...... eb in the activation of p70S6K
@nl
prefLabel
Identification of dominant neg ...... eb in the activation of p70S6K
@ast
Identification of dominant neg ...... eb in the activation of p70S6K
@en
Identification of dominant neg ...... eb in the activation of p70S6K
@en-gb
Identification of dominant neg ...... eb in the activation of p70S6K
@nl
P2093
P2860
P3181
P356
P1476
Identification of dominant neg ...... eb in the activation of p70S6K
@en
P2093
Angel P Tabancay
Chia-Ling Gau
Erik J Uhlmann
Fuyuhiko Tamanoi
Iara M P Machado
P2860
P304
P3181
P356
10.1074/JBC.M306553200
P407
P577
2003-10-10T00:00:00Z