Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
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The many faces of aire in central tolerancePost-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific AutoantigensStructure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulatorAire and T cell developmentInduction of central tolerance by the factor Aire: molecular and epigenetic regulationThymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance InductionOvarian autoimmune disease: clinical concepts and animal modelsLymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patientsThe solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylationAutoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytesPositive and negative selection of the T cell repertoire: what thymocytes see (and don't see)Autoimmune gastro-pancreatitis with anti-protein disulfide isomerase-associated 2 autoantibody in Aire-deficient BALB/cAnN miceChronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.Genetic control of programmed cell death during animal development.Thymic nurse cells exhibit epithelial progenitor phenotype and create unique extra-cytoplasmic membrane space for thymocyte selectionHuman peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cellsChagasic thymic atrophy does not affect negative selection but results in the export of activated CD4+CD8+ T cells in severe forms of human disease.The kinetics of early T and B cell immune recovery after bone marrow transplantation in RAG-2-deficient SCID patients.The immune response to melanoma is limited by thymic selection of self-antigensEpigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells.APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility FactorsBoth polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells.Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.Role and therapeutic value of dendritic cells in central nervous system autoimmunity.Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.Multiorgan autoimmune manifestations associated with thymoma.Medullary thymic epithelial cells and central tolerance in autoimmune hepatitis development: novel perspective from a new mouse model.Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis.Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cellsIntercellular Protein Transfer from Thymocytes to Thymic Epithelial CellsSequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.Aire controls gene expression in the thymic epithelium with ordered stochasticityIntronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymusAire's plant homeodomain(PHD)-2 is critical for induction of immunological toleranceAbsence of some common organ-specific and non-organ-specific autoimmunity in autoimmune polyendocrinopathy candidiasis ectodermal dystrophyUbiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selectionHuman APECED; a Sick Thymus Syndrome?Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.
P2860
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P2860
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@ast
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@en
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@nl
type
label
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@ast
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@en
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@nl
prefLabel
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@ast
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@en
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@nl
P2860
P50
P3181
P356
P1476
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
@en
P2860
P304
P3181
P356
10.1038/NRI2450
P407
P577
2008-12-01T00:00:00Z