An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
about
The many faces of aire in central toleranceAutoimmune polyendocrinopathy candidiasis ectodermal dystrophy: insights into genotype-phenotype correlationExpression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral toleranceSolution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domainThe autoimmune regulator (AIRE) is a DNA-binding proteinNeuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myelomaAn immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family.Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy proteinHomozygosity and linkage-disequilibrium mapping of the syndrome of congenital hypoparathyroidism, growth and mental retardation, and dysmorphism to a 1-cM interval on chromosome 1q42-43Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivatorAire and T cell developmentJM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndromeTranscriptional regulation by AIRE: molecular mechanisms of central toleranceDeletional tolerance mediated by extrathymic Aire-expressing cellsMutations in NR5A1 associated with ovarian insufficiencyA homozygous CARD9 mutation in a family with susceptibility to fungal infectionsAutoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunityAutoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the diseaseRheumatoid arthritis viewed using a headache paradigm.Thymic and Postthymic Regulation of Naïve CD4(+) T-Cell Lineage Fates in Humans and Mice ModelsThe Contribution of Chemokines and Migration to the Induction of Central Tolerance in the ThymusThe Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central ToleranceThymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance InductionOvarian autoimmune disease: clinical concepts and animal modelsBreaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunityT-regulatory cells in primary immune deficienciesThe genetic basis of female reproductive disorders: etiology and clinical testingUbiquitin in the immune systemAutoimmune polyendocrine syndrome type 1: case report and review of literatureMaturation and migration of murine CD4 single positive thymocytes and thymic emigrantsInsights into type 1 diabetes from the autoimmune polyendocrine syndromesAIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactomeAdult thymic epithelial cell (TEC) progenitors and TEC stem cells: Models and mechanisms for TEC development and maintenanceAutoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristicsThe autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding proteinAPECED mutations in the autoimmune regulator (AIRE) geneA 20-year-old woman with Hashimoto's thyroiditis and Evans' syndromeCentral tolerance: learning self-control in the thymus
P2860
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P2860
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@ast
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@en
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@en-gb
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@nl
type
label
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@ast
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@en
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@en-gb
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@nl
prefLabel
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@ast
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@en
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@en-gb
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@nl
P2860
P3181
P356
P1433
P1476
An autoimmune disease, APECED, ...... o PHD-type zinc-finger domains
@en
P2860
P2888
P304
P3181
P356
10.1038/NG1297-399
P407
P577
1997-12-01T00:00:00Z
P6179
1003528367