Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence - Test2 - elhamkhani - TriplyDB

Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence

Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence

http://www.wikidata.org/entity/Q24650175

about

Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas ING2 controls the progression of DNA replication forks to maintain genome stability MicroRNA let-7: an emerging next-generation cancer therapeutic miR-221 overexpression contributes to liver tumorigenesis MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 Keep-ING balance: tumor suppression by epigenetic regulation The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration.The miR-34 family in cancer and apoptosis The p53 circuit board Modeling of miRNA and drug action in the EGFR signaling pathway p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication Open access to high-content clonogenic analysis.11q deletion in neuroblastoma: a review of biological and clinical implications.Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment.ING proteins as potential anticancer drug targets.p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence Awakening p53 in senescent cells using nutlin-3.Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate.Role of miR-34c microRNA in the late steps of spermatogenesis.Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation The ING gene family in the regulation of cell growth and tumorigenesis.Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel.Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest.MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1.MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.microRNA profiling in three main stages during porcine spermatogenesis.p53: guardian of ploidy E2F1-dependent oncogenic addiction of melanoma cells to MDM2.A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway Ionizing radiation-induced microRNA expression changes in cultured RGC-5 cells.Converging miRNA functions in diverse brain disorders: a case for miR-124 and miR-126.Cellular senescence and cancer chemotherapy resistance.Regulation of senescence by microRNA biogenesis factors Lamin B1 loss is a senescence-associated biomarker.An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells.miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis

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P2860

Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence

http://www.wikidata.org/entity/Q24650175

description

2008 nî lūn-bûn

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2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2008 թվականի մայիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@ast

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@en

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@nl

type

label

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@ast

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@en

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@nl

prefLabel

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@ast

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

@en

Nutlin-3a activates p53 to bot ...... ression, and induce senescence

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0008-5472.CAN-07-2780

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Cancer Research

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Nutlin-3a activates p53 to bot ...... ression, and induce senescence

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Curtis C Harris

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Elisa A Spillare

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Izumi Horikawa

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Jun Yokota

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Kaori Fujita

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Kensuke Kumamoto

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Makoto Nagashima

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Seiichi Takenoshita

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Taro Yamashita

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P2860

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Mdm2 promotes the rapid degradation of p53

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation

DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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3193-203

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357898

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9

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18451145

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2440635

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