In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 - Test2 - elhamkhani - TriplyDB

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

http://www.wikidata.org/entity/Q27642888

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Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands S100A4 interacts with p53 in the nucleus and promotes p53 degradation Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells Regulation of p53 stability and function by the deubiquitinating enzyme USP42 Identification of HEXIM1 as a positive regulator of p53 Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH Myosin VI is a mediator of the p53-dependent cell survival pathway.RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation MDM4 binds ligands via a mechanism in which disordered regions become structured TSPYL5 suppresses p53 levels and function by physical interaction with USP7 Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain An essential function of the extreme C-terminus of MDM2 can be provided by MDMX p53 regulates Period2 expression and the circadian clock MdmX is a substrate for the deubiquitinating enzyme USP2a Mdm2 targets the p53 transcription cofactor JMY for degradation Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol Specific small molecule inhibitors of Skp2-mediated p27 degradation Visualization and targeted disruption of protein interactions in living cells Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma Structural conservation of druggable hot spots in protein-protein interfaces Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53 The first 30 years of p53: growing ever more complex Identifying druggable disease-modifying gene products Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 Regulation of autophagy by cytoplasmic p53 Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

P2860

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P2860

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

http://www.wikidata.org/entity/Q27642888

description

2004 nî lūn-bûn

@nan

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

@ast

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

@en

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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type

label

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

@ast

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

@en

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

@nl

prefLabel

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

@ast

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

@en

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Binh T Vu

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Bradford Graves

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Christian Klein

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Christine Lukacs

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Daisy Carvajal

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Emily A Liu

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Frank Podlaski

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Lyubomir T Vassilev

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Norman Kong

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