Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway - Test2 - elhamkhani - TriplyDB

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

http://www.wikidata.org/entity/Q24650927

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Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression Cancer Stem Cell Hierarchy in Glioblastoma Multiforme Clinical Potential of microRNA-7 in Cancer Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets Brain tumor stem cells: Molecular characteristics and their impact on therapy STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1 STAT3 negatively regulates thyroid tumorigenesis The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells.Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter.EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance.Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling.Role of STAT3 in cancer metastasis and translational advances.Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1 STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner.Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.Celecoxib suppresses the phosphorylation of STAT3 protein and can enhance the radiosensitivity of medulloblastoma-derived cancer stem-like cells.Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma.COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport.Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus.Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation.Nuclear localization of signal transducer and activator of transcription 3 in head and neck squamous cell carcinoma is associated with a better prognosis Rescue of MHC-1 antigen processing machinery by down-regulation in expression of IGF-1 in human glioblastoma cells.The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma miR-21: a small multi-faceted RNA.Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

P2860

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P2860

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

http://www.wikidata.org/entity/Q24650927

description

2008 nî lūn-bûn

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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2008 թվականի փետրվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@ast

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@nl

type

label

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@ast

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@en

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@nl

prefLabel

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@ast

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@en

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

@nl

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

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Azad Bonni

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Jennifer A Chan

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Mingjian J You

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Núria de la Iglesia

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Robert M Bachoo

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Ronald A Depinho

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P2860

Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

The phosphoinositide 3-kinase pathway

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Coordinated histone modifications mediated by a CtBP co-repressor complex

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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449-62

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10.1101/GAD.1606508

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4

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22

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Genevieve Konopka

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5592981

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2238667

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