A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. - Test2 - elhamkhani - TriplyDB

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

http://www.wikidata.org/entity/Q30156063

about

STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis Radioresistance of Brain Tumors Insight to drug delivery aspects for colorectal cancer Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer Cells Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.STAT3 Inhibition as a Therapeutic Strategy for Chordoma.Myeloid derived suppressor cells - a new therapeutic target in the treatment of cancer.STAT inhibitors for cancer therapy.Therapeutic modulators of STAT signalling for human diseases Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways.Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer.The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres.The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling.Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma New insights into the roles of ncRNA in the STAT3 pathway.hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes.Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6.Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies.Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation.Targeting histone methylation for colorectal cancer Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.Manipulation of autophagy in cancer cells: an innovative strategy to fight drug resistance.XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells.Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways.MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients.Myeloid-Derived Suppressor Cells in the Tumor Microenvironment: Current Knowledge and Future Perspectives.Targeting Myeloid-Derived Suppressor Cells in Cancer.Dual-inhibitors of STAT5 and STAT3: studies from molecular docking and molecular dynamics simulations.A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)

P2860

Q24300906-9ECA88E6-4C60-4B85-9E8B-D6AACF0CF1BB Q26752579-2AA6883C-0A9B-4A9F-9818-D3E5CB9FFFCB Q26774682-19DCB426-C686-4242-8613-1260DC1A2488 Q28080262-98196518-3603-4506-AB22-687B1C7E737F Q28383151-72B7C49C-C376-4B0D-BDC7-6CB88F725DA0 Q31085777-AEB34509-CCFA-4E67-AE3C-71C58090ECE3 Q33274011-97A20344-2549-4A05-9344-8C6493724F33 Q33276283-489DEBF1-BFF9-4C73-8967-33648589AF65 Q33606107-93E19EDA-17E5-4C8B-BE9A-0D3A58C0B143 Q33644206-25619BFF-251A-467E-AD11-661648C9FCAD Q33684732-00019936-5473-4CDD-BDCB-E0F0D7401A8B Q33757981-04AED4CB-9931-455F-B807-9CB64E60AA6F Q34252516-708CA733-9353-4C54-A538-6A2EC0FCBDF9 Q34279156-66D53BE6-138C-469D-95F7-D55FC66ADA42 Q34781882-858C29BB-ECA6-4ECC-8682-9E54A8DCE74D Q34796500-FD4F8516-7D30-4BE2-BCDB-71B5C6E7BE68 Q35132241-B8B829F7-2394-437C-B1A0-F208C2BCF20E Q35225869-C23BDED2-C6BA-46CB-B6C8-06961A724470 Q35964637-EE528BD4-2A66-43D8-9A48-5F8E9AC2E2DC Q36160710-E20465C9-7041-4E06-91D8-BC18F19B2B0D Q36579336-CD314CA7-E6D7-476C-BFE7-713EEA4AFCB0 Q36998357-CE0766CE-3E3D-46F2-B781-7F90917B7738 Q37295655-9773CD4E-D751-458D-89E9-8223F85CB496 Q38024125-E63AD85E-5545-47A8-89A9-6E444AFB4018 Q38308505-2A2CE8E8-E4CA-4B7C-B83C-957645608FFA Q38979718-49E39808-3716-42AE-886A-AF96DB6775BE Q39044440-8ABA4C5A-AA92-4BB1-A668-986AE5F80952 Q39057993-68780E93-90C2-46C1-8448-FB2D679B87E4 Q39175486-E9DFD860-F273-49C7-A3DB-B40A209B6342 Q39186157-57BA0862-BFAB-4DD5-A112-CBA9B867DF30 Q39407829-BA5309A1-0E77-4A22-9680-1B73C2137656 Q39594191-1BEE453C-3362-483F-B819-AB836EA7A12A Q41482749-1ED1823A-10EA-4315-995D-2DBC8E9BB84F Q41552170-ABAB45C8-2A8F-4BE1-9A8B-CD6274F07D31 Q43497561-74289D4B-4441-4ACB-8686-7610ABFDE4D5 Q47651773-C355EE62-9E0A-4BB4-8D4E-020B1BB879EF Q47765346-B1DFEE6B-43A4-4968-99E4-86908EB52E39 Q51064463-081C9D0C-B0D4-42E2-9CA4-71CF192A5B7B Q58704632-2DB9BD11-7B11-4008-A748-06895B248824

P2860

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

http://www.wikidata.org/entity/Q30156063

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

A novel small molecule inhibit ...... ctivity in human cancer cells.

@ast

A novel small molecule inhibit ...... ctivity in human cancer cells.

@en

type

label

A novel small molecule inhibit ...... ctivity in human cancer cells.

@ast

A novel small molecule inhibit ...... ctivity in human cancer cells.

@en

prefLabel

A novel small molecule inhibit ...... ctivity in human cancer cells.

@ast

A novel small molecule inhibit ...... ctivity in human cancer cells.

@en

P1433

Q30156063-3416A9D4-7F08-4B0D-930D-561750FF7F36

P1476

Q30156063-59A5DAAE-A98F-4946-90FC-E62A4BD29138

P2093

Q30156063-0C5DFB91-6A6A-4639-A2C6-D08F7A7CA49B

Q30156063-2A7CA2E1-5312-4C63-B056-0E46B536C6A9

Q30156063-300646F0-DBAB-4CD4-AAD6-F14BB83894AA

Q30156063-3CF9621A-913C-49D7-9624-56C17D144775

Q30156063-5FD1510B-6ED8-46B3-A788-54D29887224E

Q30156063-7F58BA4E-403C-43D0-953A-201B567358DA

Q30156063-8632C3DF-5F4A-40E8-91B9-832EDD6D9E32

Q30156063-8F2EE50B-CCBB-4C6D-B705-3B949DDD0988

Q30156063-9FF82C49-67CB-4758-9AA3-D4D0D4947785

Q30156063-AA1DD1F7-25F5-4A92-83EF-8DA0932B3A88

P2860

Q30156063-04184B2F-923D-402C-A30F-FBF4FBA2CB7A

Q30156063-076F96AC-7283-4DF3-BC96-8D8921F771C6

Q30156063-09EF34E1-D466-4AED-8BC3-464E6446646C

Q30156063-24605548-8A59-49A9-9168-C5FECEB54013

Q30156063-2A39CC9B-03B6-4704-9B4F-AA2435763183

Q30156063-2C7EED63-3581-4D26-8405-1D5397963496

Q30156063-3367A2E2-C92C-445C-864B-B8731FAB7099

Q30156063-337816D9-BCF1-4D4F-BD1A-AB75D84FA2EA

Q30156063-435BC48A-3824-44A7-A22F-7D39F521860B

Q30156063-4426953E-16D2-4B05-928A-469AAED75E75

P2888

Q30156063-2A390B37-759D-4F8A-A935-F2AA18F92C68

P304

Q30156063-355DA7E1-9EBF-4422-82E6-3BFA8C5DF04A

P31

Q30156063-2CAC4580-55B8-462D-B7FF-9EB5B4680660

P356

Q30156063-64554700-F947-4B72-B8EC-688A952BD5BF

P478

Q30156063-3A11056E-AD9C-425D-8CD0-122572EEF0A1

P577

Q30156063-12F48EA8-9B4D-4150-9D9D-C65A170D0D9E

P5875

Q30156063-2970A985-B282-4113-B18B-1C9DF25D7BD0

P6179

Q30156063-9DD4CB73-B7F7-47DA-AC36-270693F5EAC9

P698

Q30156063-B54EBCEB-402D-4E62-B2EA-82D1128EAB2D

P921

Q30156063-AE805DF9-6DB1-48A1-8DE1-C0FEDAD136BC

P932

Q30156063-B6CF8F35-68A1-4485-B7B2-3C83C909E236

P356

1476-4598-9-217

P1433

Molecular Cancer

P1476

A novel small molecule inhibit ...... ctivity in human cancer cells.

@en

P2093

Chenglong Li

http://www.w3.org/2001/XMLSchema#string

Dale Hoyt

http://www.w3.org/2001/XMLSchema#string

Don Benson

http://www.w3.org/2001/XMLSchema#string

Elizabeth Foust

http://www.w3.org/2001/XMLSchema#string

Eric B Schwartz

http://www.w3.org/2001/XMLSchema#string

Gregory B Lesinski

http://www.w3.org/2001/XMLSchema#string

James Fuchs

http://www.w3.org/2001/XMLSchema#string

Jiagao Lü

http://www.w3.org/2001/XMLSchema#string

Jiayuh Lin

http://www.w3.org/2001/XMLSchema#string

Li Lin

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Rac1 mediates STAT3 activation by autocrine IL-6

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells.

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.

Molecular targets of dietary agents for prevention and therapy of cancer.

Curcumin: from ancient medicine to current clinical trials.

P2888

1476-4598-9-217

P304

217

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1186/1476-4598-9-217

http://www.w3.org/2001/XMLSchema#string

P478

9

http://www.w3.org/2001/XMLSchema#string

P577

2010-08-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45659215

http://www.w3.org/2001/XMLSchema#string

P6179

1052907373

http://www.w3.org/2001/XMLSchema#string

P698

20712901

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

2936338

http://www.w3.org/2001/XMLSchema#string