The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors
about
Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking CessationStructural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptorsPhotoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL.Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiationA portable site: a binding element for 17β-estradiol can be placed on any subunit of a nicotinic α4β2 receptorEnergetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit.Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior.Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor.Levamisole receptors: a second awakening.Function of human α3β4α5 nicotinic acetylcholine receptors is reduced by the α5(D398N) variantA Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α SubunitPhotolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator.Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed.Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.The unique α4+/-α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(β2)3 subtypeIntra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites!Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.Mechanism of Allosteric Modulation of the Cys-loop Receptors.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.Physostigmine and galanthamine bind in the presence of agonist at the canonical and noncanonical subunit interfaces of a nicotinic acetylcholine receptor.Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor.The fifth subunit of the (α4β2)2 β2 nicotinic ACh receptor modulates maximal ACh responses.Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses.Determination of the Residues in the Extracellular Domain of the Nicotinic α Subunit Required for the Actions of Physostigmine on Neuronal Nicotinic Receptors.The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors.
P2860
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P2860
The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The positive allosteric modula ...... otinic acetylcholine receptors
@ast
The positive allosteric modula ...... otinic acetylcholine receptors
@en
The positive allosteric modula ...... otinic acetylcholine receptors
@nl
type
label
The positive allosteric modula ...... otinic acetylcholine receptors
@ast
The positive allosteric modula ...... otinic acetylcholine receptors
@en
The positive allosteric modula ...... otinic acetylcholine receptors
@nl
prefLabel
The positive allosteric modula ...... otinic acetylcholine receptors
@ast
The positive allosteric modula ...... otinic acetylcholine receptors
@en
The positive allosteric modula ...... otinic acetylcholine receptors
@nl
P2093
P2860
P1476
The positive allosteric modula ...... otinic acetylcholine receptors
@en
P2093
Amanda H Lewis
Jonathan T Henry
Mark M Levandoski
P2860
P304
P356
10.1523/JNEUROSCI.1859-09.2009
P407
P50
P577
2009-07-01T00:00:00Z