Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
about
Activation and inhibition of TMEM16A calcium-activated chloride channelsOn the activation of soluble guanylyl cyclase by nitric oxide.End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseVoltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loopHow ATP inhibits the open K(ATP) channelThe positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptorsKinetic determinants of agonist action at the recombinant human glycine receptorThe receptor concept: pharmacology's big ideaDifferential agonist sensitivity of glycine receptor alpha2 subunit splice variantsFormation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approachActivation of single heteromeric GABA(A) receptor ion channels by full and partial agonistsTaking the time to study competitive antagonismInteraction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependentA homotropic two-state model and auto-antagonismThe "Transport Specificity Ratio": a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysisThe impact of human hyperekplexia mutations on glycine receptor structure and functionExploring the ATP-binding site of P2X receptorsA novel type of allosteric regulation: functional cooperativity in monomeric proteinsEpilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different MechanismsStructure and Rearrangements in the Carboxy-Terminal Region of SpIH ChannelsStructural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelA Structural Determinant for the Control of PIP2 Sensitivity in G Protein-gated Inward Rectifier K+ ChannelsLigand-specific deactivation time course of GluN1/GluN2D NMDA receptorsLigand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELICInhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent CationsThe Loss of an Electrostatic Contact Unique to AMPA Receptor Ligand Binding Domain 2 Slows Channel ActivationMolecular interactions involved in proton-dependent gating in KcsA potassium channelsFunctional studies cast light on receptor statesAgonist induction, conformational selection, and mutant receptorsFunctional consequences of progressive cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunitAllosteric activation mechanism of the cys-loop receptorsOrthosteric and allosteric binding sites of P2X receptorsMapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete modelMutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC(2): role of basic residues in the second transmembrane helixSelective blocking effects of tropisetron and atropine on recombinant glycine receptorsIdentifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screenMolecular mechanism for the dual alcohol modulation of Cys-loop receptorsMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsInfluence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptorsCharacterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells
P2860
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P2860
Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Binding, gating, affinity and ...... effects of mutating receptors
@ast
Binding, gating, affinity and ...... effects of mutating receptors
@en
Binding, gating, affinity and ...... effects of mutating receptors
@nl
type
label
Binding, gating, affinity and ...... effects of mutating receptors
@ast
Binding, gating, affinity and ...... effects of mutating receptors
@en
Binding, gating, affinity and ...... effects of mutating receptors
@nl
prefLabel
Binding, gating, affinity and ...... effects of mutating receptors
@ast
Binding, gating, affinity and ...... effects of mutating receptors
@en
Binding, gating, affinity and ...... effects of mutating receptors
@nl
P3181
P356
P1476
Binding, gating, affinity and ...... effects of mutating receptors
@en
P2093
D Colquhoun
P304
P3181
P356
10.1038/SJ.BJP.0702164
P407
P577
1998-11-01T00:00:00Z