TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing - Test2 - elhamkhani - TriplyDB

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

http://www.wikidata.org/entity/Q24651520

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Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes TDP-43 identified from a genome wide RNAi screen for SOD1 regulators The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.TDP-43 is a developmentally regulated protein essential for early embryonic development.Quantitative analysis of cryptic splicing associated with TDP-43 depletion.Neuronal function and dysfunction of Drosophila dTDP Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.SMN-inducing compounds for the treatment of spinal muscular atrophy.Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration.TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice Targeting SR proteins improves SMN expression in spinal muscular atrophy cells.TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling Transgenic animal models of neurodegeneration based on human genetic studies.Targeting RNA binding proteins involved in neurodegeneration.Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies.Rodent models of TDP-43 proteinopathy: investigating the mechanisms of TDP-43-mediated neurodegeneration TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology.Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.Regulation of autophagy by neuropathological protein TDP-43.Altered RNA metabolism and amyotrophic lateral sclerosis Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.

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P2860

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

http://www.wikidata.org/entity/Q24651520

description

2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

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Journal of Biological Chemistry

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TDP-43 overexpression enhances ...... motor neuron pre-mRNA splicing

@en

P2093

C-K James Shen

http://www.w3.org/2001/XMLSchema#string

I-Fan Wang

http://www.w3.org/2001/XMLSchema#string

Jayarama Krishnan Bose

http://www.w3.org/2001/XMLSchema#string

Li Hung

http://www.w3.org/2001/XMLSchema#string

Woan-Yuh Tarn

http://www.w3.org/2001/XMLSchema#string

P2860

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding

hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1

Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs

Higher order arrangement of the eukaryotic nuclear bodies.

Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene.

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1

Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

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10.1074/JBC.M805376200

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283

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18703504

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2661999

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